药学学报, 2003, 38(9): 711-714
引用本文:
张真庆;赵峡;管华诗. 古糖酯的稳定性研究[J]. 药学学报, 2003, 38(9): 711-714.
ZHANG Zhen-qing ; ZHAO Xia; GUAN Hua-shi. Stability studies of sulfated polyguluronic acid ester[J]. Acta Pharmaceutica Sinica, 2003, 38(9): 711-714.

古糖酯的稳定性研究
张真庆;赵峡;管华诗
中国海洋大学 药物与食品研究所,山东 青岛 266003
摘要:
目的探讨古糖酯的稳定性。方法本文采用凝胶色谱(HPGC),聚丙烯酰胺凝胶电泳(PAGE),紫外扫描,明胶比浊法来考察古糖酯在高温、高湿、强光照射及加速条件下分子量和分子量分布宽度及样品中硫酸根含量的变化情况。结果这几种方法适用于古糖酯的稳定性考察,在高温60 ℃和80 ℃条件下样品有所降解,80 ℃条件下更为明显,其他条件下样品稳定性良好。结论古糖酯具有良好的稳定性。
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Stability studies of sulfated polyguluronic acid ester
ZHANG Zhen-qing ; ZHAO Xia; GUAN Hua-shi
Abstract:
AimTo test the stability of marine polysaccharide drug sulfated polyguluronic acid ester. MethodsFour methods including high performance gel chromatography (HPGC),poly-acrylamide gel electrophoresis (PAGE), UV scan of absorbance between 200 and 800 nm and gelatin nephelometry were estabilished. Samples were tested in high temperature, high humidity, strong light and accelerated test conditions. The methods were used to test the changes of the parameters including molecular weight, molecular weight distribution, absorbance between 200 and 800 nm, free sulfate, with which we could estimate the stability of sulfated polyguluronic acid ester could be estimated. ResultsThe four methods were suitable to test the stability of sulfated polyguluronic acid ester and the sample were stable in the conditions as before except in high temperature. ConclusionSulfated polyguluronic acid ester has good stability.
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