药学学报, 1988, 23(3): 213-217
引用本文:
王林;董永明. 可逆性胆碱酯酶抑制剂二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯的合成[J]. 药学学报, 1988, 23(3): 213-217.
L Wang and YM Dong. SYNTHESIS OF 3-(ALKYLAMINO) ALKOXY-4(5)-t-BUTYLPHENYL N, N-DIMETHYLCARBAMATES AS REVERSIBLE CHOLINESTERASE INHIBITORS[J]. Acta Pharmaceutica Sinica, 1988, 23(3): 213-217.

可逆性胆碱酯酶抑制剂二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯的合成
王林;董永明
军事医学科学院毒物药物研究所,北京
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SYNTHESIS OF 3-(ALKYLAMINO) ALKOXY-4(5)-t-BUTYLPHENYL N, N-DIMETHYLCARBAMATES AS REVERSIBLE CHOLINESTERASE INHIBITORS
L Wang and YM Dong
Abstract:
A series of 3-(dialkylamino) alkoxy-4 (5)-t-butylphenyl N, N-dimethylcarbamates(Ⅰ and Ⅱ), which are the nuclear alkylated derivatives of 3-(2-dimethylamino) ethoxyphenyl N, N-dimethylcarbamate (CUI XING AN) was prepared as potential anticholinesterase agents. Preliminary screening tests showed that the introduction of t-butyl group in CUI XING AN and its homologs decreased the toxicity and anticholinesterase activity. Compounds of type Ⅰ have increased protective activity against organophosphorus poisoning.
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