药学学报, 1966, 13(3): 195-203
引用本文:
饶曼人. 关于“乌头、附子”强心作用的研究[J]. 药学学报, 1966, 13(3): 195-203.
LAO MEN-REN. Study on Cardiac Action of Chinese Aconite[J]. Acta Pharmaceutica Sinica, 1966, 13(3): 195-203.

关于“乌头、附子”强心作用的研究
饶曼人
南京医学院药理教研组
摘要:
用南京地区所产的中国乌头及经过炮制后的川附子(熟附片)煎剂,在离体心脏(蟾蜍、蛙、豚鼠、兔)标本上进行了试验,证明有强心作用。熟附片煎剂对在位心脏(蛙、猫、犬)亦表现轻度强心作用,而中国乌头只有毒性影响。经化学分析,其中不含强心甙,却含较高量的钙,乌头为0.24%,熟附片1.41%。也含有鞣酸0.8%,钾离子0.47%。煎煑愈久,煎剂中钙含量也有相应增高。以EDTA络合法,离子交换树脂,草酸铵除去钙后则强心作用消失,但对特异性较低的蟾蜍离体心脏,有时可出现强心作用。乌头及熟附片在蛙心上增强心脏收缩及拮抗乌头碱的作用与钙颇相似,因而认为乌头、附子煎剂的强心作用与其中所含的钙有密切关系。总碱对蛙心的作用与乌头碱基本一致,未发现总碱中水解产物有明显的强心作用。
关键词:   
Study on Cardiac Action of Chinese Aconite
LAO MEN-REN
Abstract:
In Chinese medicine, Fu-Tze (附子), the daughter root of Chinese aconite, has been used as a circulatory stimulant for thousands of years. As a rule, the drug prescribed has previously been subjected to various treatments, which is known as Fu-Pi (附片) in Chinese drug store. Recently several authors claimed that galenic preparat of aconite has a cardiotonic effect. We have repeated experiments and partly confirmed some of their results and shown that the decoction of Fu-Pi has a cardiotonic effect not only on the Straub's toad and frog heart but also on the isolated heart of rabbit, guinea pig and rat. A slight cardiotonic effect has also been observed on cat's and dog's heart in situ by decoction of Fu-Pi, but not by decoction of aconite. On the frog heart in situ, a characterized glycoside effect has never been observed by this drug injected in lymph sac. Chemical analysis also showed that it contained no glycoside, but a larger quantity of calcium ion (especially in the decoctum of Fu-Pi), tannic acid and some potassium ion. When calcium ion had been excluded by several methods (ion exchange, sedimentation with ammonium oxalate and chelation with EDTA), the decoction loses its cardiotonic effect at once. Simple solution of calcium ion in the concentration lower than those contained in decoction of aconite has also a similar cardiotonic effect. It is therefore concluded that the so-called cardiotonic effect of the decoction of aconite is closely related to the calcium it contains. The effect of total alkaloid of aconite on isolated heart is similar to those of aconitine. No significant cardiotonic effect has been observed by any product of hydrolysation of total alkaloid.
Key words:   
收稿日期:
相关功能
PDF(526KB) Free
打印本文
0
作者相关文章