药学学报, 1991, 26(7): 493-498
引用本文:
杨玉龙;卢志英;杨志杰;赵淑媛;张金宝;肖鲁沂. 4-甲氧甲基芬太尼类似物的合成及其镇痛作用[J]. 药学学报, 1991, 26(7): 493-498.
YL Yang; ZY Lu; ZJ Yang; SY Zhao; JB Zhang and LY Xiao. SYNTHESIS AND ANALGESIC ACTIVITY OF ANALOGS OF 4-METHOXYMETHYL FENTANYL[J]. Acta Pharmaceutica Sinica, 1991, 26(7): 493-498.

4-甲氧甲基芬太尼类似物的合成及其镇痛作用
杨玉龙;卢志英;杨志杰;赵淑媛;张金宝;肖鲁沂
中国人民解放军药物化学研究所,北京102205;*现址:南京军区南京总医院药物研究所 邮政编码 210002
摘要:
本文报道了某些N-[1-(2-苯乙基)-4-甲氧甲基-4-哌啶基]-N-丙酰苯胺(4-甲氧甲基芬太尼)类似物的合成及其镇痛活性。小白鼠热板试验的结果表明,该类化合物有很强的吗啡样镇痛活性,但活性弱于相应的4-甲氧羰基芬太尼类化合物;4-N-酰基上羰基的存在对产生强效镇痛活性有重要作用。
关键词:   
SYNTHESIS AND ANALGESIC ACTIVITY OF ANALOGS OF 4-METHOXYMETHYL FENTANYL
YL Yang; ZY Lu; ZJ Yang; SY Zhao; JB Zhang and LY Xiao
Abstract:
In this paper, the synthesis and analgesic activities of some derivatives of N- [1-( 2-phenylethyl )- 4- methoxymethyl-4- piperidinyl]-N-propionylaniline (4-methoxymethyl fentanyl )are reported. In mouse hot plate test, most compounds in this series showed strong narcotic analgesic activities but their activities were lower than those of compounds in the series of 4-methoxycarbonyl fentanyl.
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