药学学报, 1992, 27(4): 299-302
引用本文:
陈秋潮;陈伟力;戴幼琴;葛国庆;林德昌. 苯丙醇胺控释混悬剂在健康志愿者的生物利用度[J]. 药学学报, 1992, 27(4): 299-302.
QC Chen;WL Chen;YQ Dai;GQ Ge;DC Lin Zhongshan. BIOAVAILABILITY OF A CONTROLLED-RELEASE SUSPENSION OF PHENYLPROPANOLAMINE IN HEALTHY VOLUNTEERS[J]. Acta Pharmaceutica Sinica, 1992, 27(4): 299-302.

苯丙醇胺控释混悬剂在健康志愿者的生物利用度
陈秋潮;陈伟力;戴幼琴;葛国庆;林德昌
上海医科大学附属中山医院临床药理室,上海200032;**宁波市第二人民医院,进修生;*上海延安制药厂制剂研究室,上海200050
摘要:
研究建立了HPLC测定苯丙醇胺(PPA)体内血药浓度的方法,比较了10名正常受试者单剂量口服苯丙醇胺控释混悬剂(含PPA 150mg)与等剂量的普通PPA片的生物利用度,结果两者AU0~∞无显著性差异P>0.4,相对生物利用度F=102.6%。
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BIOAVAILABILITY OF A CONTROLLED-RELEASE SUSPENSION OF PHENYLPROPANOLAMINE IN HEALTHY VOLUNTEERS
QC Chen;WL Chen;YQ Dai;GQ Ge;DC Lin Zhongshan
Abstract:
A high- performance liquid chromatographic analysis ofphenylpropanolamine (PPA) in human plasma is presented. Using direct UV detectionthe method is sufficiently sensitive to 25 ng/ml for PPA. Single-dose pharmacokineticsof PPA in 10 healthy volunteers taking controlled release suspension (C) or tablet (T),each containing 150 mg PPA was compared. The study described here has shown thatthe (C) AUC0~∞/(T) AUC0~∞ = 1.02(P>0.4). The controlled-release product ofPPA is equivalent to PPA tablet.
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