药学学报, 1992, 27(4): 256-260
引用本文:
韩光范;欧阳杰;王进军;焦淑萍;姜贵吉. 6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成及镇痛作用[J]. 药学学报, 1992, 27(4): 256-260.
GF Han;J Ouyang;JJ Wang;SP Jiao;GJ Jiang. SYNTHESIS AND ANALGESIC ACTION OF 6,7-METHYLENEDIOXY—1(2H,4H)-ACRIDONE DERIVATIVES[J]. Acta Pharmaceutica Sinica, 1992, 27(4): 256-260.

6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成及镇痛作用
韩光范;欧阳杰;王进军;焦淑萍;姜贵吉
吉林医学院检验系,吉林132001;*吉林化工学院精细化工系,吉林132022;**延边大学化学系,延吉132032
摘要:
报道13个6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成。初步药理实验表明:合成的化合物均有不同程度的镇痛作用,其中化合物Ⅱe的镇痛效力最强。
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SYNTHESIS AND ANALGESIC ACTION OF 6,7-METHYLENEDIOXY—1(2H,4H)-ACRIDONE DERIVATIVES
GF Han;J Ouyang;JJ Wang;SP Jiao;GJ Jiang
Abstract:
Thirteen derivatives of 6, 7-methylenedioxy-1 (2H, 4H)-acridonewere prepared. The structures of all the compounds synthesized were characterized byelemental analysis, IR and 1HNMR spectra. Compounds Ⅱa, Ⅱb, Ⅱd, Ⅱe, Ⅱf increased significantly the pain threshold using thehot- plate method.
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