药学学报, 1992, 27(4): 303-307
引用本文:
陆彬;贺英菊;郭平;叶利民. 法莫替丁片的溶出度与生物利用度[J]. 药学学报, 1992, 27(4): 303-307.
B Lu;YJ He;P Guo;LM Ye. DISSOLUTION RATE AND BIOAVAILABILITY OF FAMOTIDINE TABLETS[J]. Acta Pharmaceutica Sinica, 1992, 27(4): 303-307.

法莫替丁片的溶出度与生物利用度
陆彬;贺英菊;郭平;叶利民
华西医科大学药学院,成都610041
摘要:
采用溶出度自动测试系统测定了法莫替丁片的溶出度,15min平均累积溶出97.40±0.31%。6名志愿健康受试者口服法莫替丁片40mg后,用HPLC柱切换技术测定其血药浓度,将不同血药浓度对时间的数据进行曲线拟合,计算值与实测值比较,可用一室模型描述。以统计矩计算得T1/2=2.92h,与口服溶液相比,Frel=118.8%。
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DISSOLUTION RATE AND BIOAVAILABILITY OF FAMOTIDINE TABLETS
B Lu;YJ He;P Guo;LM Ye
Abstract:
An automated dissolution test system was used for the determination ofthe dissolution rate of famotidine tablets, and a mean cumulative dissolution rate of97.40±0. 31% in 15 rain was obtained. To each of six healthy volunteers, 40mg offamotidine tablets were administered orally, then an automated HPLC with switching co-lumm system was used to analyze famotidine in plasma. Variation of drug concentrationvs time were fitted to curves. By comparison of calculated values with observed ones, theresults could be described as one- compartment model in human. According to a statisticmoment algorithm, the results of calculation showed that T1/2= 2.92 h and Frel= 118.8%.
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