药学学报, 1991, 26(7): 531-536
引用本文:
杨秀岑;李耀根;肖志芳;刘惠佳;刘鹏先. 伯氨喹在乙醇—水混合溶剂中离解常数的测定及其与维生素C的配合比研究[J]. 药学学报, 1991, 26(7): 531-536.
XC Yang; YG Li; ZF Xiao; HJ Liu and PX Liu . DETERMINATION OF IONIZATION CONSTANTS OF PRIMAQUINE AND STUDY OF ITS COORDINATION RATIO WITH VITAMIN C[J]. Acta Pharmaceutica Sinica, 1991, 26(7): 531-536.

伯氨喹在乙醇—水混合溶剂中离解常数的测定及其与维生素C的配合比研究
杨秀岑;李耀根;肖志芳;刘惠佳;刘鹏先
华西医科大学药学院化学部,成都610041;*本校药学院1983级毕业生
摘要:
本文推导出用pH滴定法测定三元弱酸离解解常数的方程,测得25±0.01℃时,伯氨喹在乙醇—水的体积比为1:1的混合溶剂中,离子强度范围5×10-3~5×10-2mol/L时逐级离解常数为Ka1=(3.84±2.35)×10-2(归属于仲铵基),Ka2=(1.50±1.17)×10-8(归属于叔铵基),Ka3=(2.07±0.27)×10-10(归属于伯铵基)。并用pH法及电导法测得伯氨喹与维生素C在上述溶剂中的配合比为1:1。
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DETERMINATION OF IONIZATION CONSTANTS OF PRIMAQUINE AND STUDY OF ITS COORDINATION RATIO WITH VITAMIN C
XC Yang; YG Li; ZF Xiao; HJ Liu and PX Liu
Abstract:
Primaquine (P) has long been used as an antimalarial drug. The following formulas are derived for determination of the ionization constants of PH33+ by pH-titration method:in which Kw is the ionic product of water, a is the mole ratio of HClO4 to primaquine and Cp is the total concentration of rimaquine.The ionization constants of primaquine in 50% (v/v)ethanol in water determined at 25℃ in the ionic strength range of 5×10-3~ 5× 10-2 mol/L are :Ka1=( 3. 84±2. 35)× 10-2(attributed to the secondary ammonium group of primaquine) ;Ka2= (1.50±1.17 )× 10-8 (attributed to the tertiary ammonium group ) ;Ka3= (2.07± 0.27 )× 10-10 (attributed to the primary ammonium group).The coordination ratio of primaquine to vitamin C in the above solvent is determined by continuous variation and mole ratio methods based on pH and conductance measurements to be 1 : 1, indicating that the coordination compound formed in the solution is mainly a 1 : 1 compound.
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