药学学报, 1981, 16(4): 267-270
引用本文:
汪淑华;费开逵;朱应麒. 抗着床药物的研究——Ⅰ.三氟甲基三苯乙烯类衍生物的合成[J]. 药学学报, 1981, 16(4): 267-270.
Wang Shuhua; Fei Kaikui and Zhu Yingqi . STUDIES ON ANTIIMPLANTATION DRUGS——Ⅰ. SYNTHESIS OF SOME TRIFLUOROMETHYL TRIPHENYLETHYLENE DERIVATIVES[J]. Acta Pharmaceutica Sinica, 1981, 16(4): 267-270.

抗着床药物的研究——Ⅰ.三氟甲基三苯乙烯类衍生物的合成
汪淑华;费开逵;朱应麒
中国科学院上海药物研究所
摘要:
本文报道合成了具有不同取代基的三氟甲基三苯乙烯类化合物以及Ⅰb的氢化产物Ⅱ,并试验其抗着床作用。经初步药理试验发现Ⅰb(R=OCH3)与Ⅰc(R=OC2H5)作用最强,大白鼠口服给药0.03mg/kg,连续三天,有显著抗生育作用。
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STUDIES ON ANTIIMPLANTATION DRUGS——Ⅰ. SYNTHESIS OF SOME TRIFLUOROMETHYL TRIPHENYLETHYLENE DERIVATIVES
Wang Shuhua; Fei Kaikui and Zhu Yingqi
Abstract:
A series of substituted 1-trifluoromethyl-triphenylethyleneand Ⅰ-trifluoromethyl-Ⅰ, 2-diphenyl-2p-methoxy-phenylethane were synthesized. Among these the most potent compounds were Ⅰb(R=—OCH3)and Ⅰc(R=—OC2H5), both afforded marked antifertility activity in female rats when given orally at a dose of 0.030 mg/kg per day for three consecutive days.
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