药学学报, 2010, 45(4): 530-534
引用本文:
邰 文 孙敏敏 刘 楠 黄志起 聂尚海 郝艳丽 张小宁. 应用动物活体生物发光技术观察紫杉醇混合胶束的抑瘤效果[J]. 药学学报, 2010, 45(4): 530-534.
TAI Wen, Sun-Min-Min, Liu- Nan, Huang-Zhi-Qi, Nie-Chang-Hai, Hao-Yan-Li, Zhang-Xiao-Ning. Study on the anti-tumor effect of paclitaxel mixed micelle by using in vivo optical imaging technique[J]. Acta Pharmaceutica Sinica, 2010, 45(4): 530-534.

应用动物活体生物发光技术观察紫杉醇混合胶束的抑瘤效果
邰 文1, 孙敏敏1, 刘 楠1, 黄志起1, 聂尚海2, 郝艳丽1*, 张小宁1*
(1. 清华大学医学院, 北京 100084; 2. 北京东胜创新生物科技有限公司, 北京 100085)
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Study on the anti-tumor effect of paclitaxel mixed micelle by using in vivo optical imaging technique
Abstract:

In vivo tumor imaging technique method based on bioluminescence principle was established to evaluate the anti-tumor effect of paclitaxel mixed micelle (PMM).  MDA-MB-231 tumor cells with luciferase reporter vectors were firstly implanted into nude mice, and subsequently the luciferase substrate was regularly injected during intraperitoneal administration of PMM.  Then the tumor size, growth and the intensity of light signals were monitored with in vivo imaging technique.  The method of luciferase tumor in vivo imaging could be real-time, reliable and exact in labeling and reflecting the growth of tumors, and the observed results were consistent with that by conventional method, so it would be a feasible approach to study anti-tumor effect of drugs.  The anti-tumor effect of paclitaxel mixed micelle was observed by this method, and the results showed that this formulation could inhibit growth of tumor, and the anti-tumor rate of it was about 85%.

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