药学学报, 2012, 47(3): 332-338
引用本文:
于菲菲 邹 豪 钟延强. 逐层组装技术在药物递送领域应用的研究进展[J]. 药学学报, 2012, 47(3): 332-338.
XU Fei-Fei, Zou Hao, Zhong Yan-Jiang. Research progress of layer-by-layer self-assembly technique in drug delivery[J]. Acta Pharmaceutica Sinica, 2012, 47(3): 332-338.

逐层组装技术在药物递送领域应用的研究进展
于菲菲, 邹 豪, 钟延强*
(第二军医大学药学院, 上海 200433)
摘要:

逐层组装 (layer-by-layer self-assembly, LbL) 技术在生物工程、医学、药物控释及光电子学等领域的应用受到了广泛关注。其中, 运用LbL技术构建药物控释系统, 可灵活控制递药载体结构, 组装过程简单、化学温和, 递药系统用途广泛, 可达到隐蔽、靶向等效果。本文总结了逐层组装技术的优势, 讨论了影响LbL多层膜系统构建的影响因素, 综述了LbL构建的纳米粒、微凝胶和微囊等载体在药物递送系统的应用及前景。

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Research progress of layer-by-layer self-assembly technique in drug delivery
Abstract:

Now the layer-by-layer self-assembling (LbL) technique has become an attention-getting reparative methodology for ultrathin film formation.  Many scientists in different academic areas including bioengieering, medical science, drug controlled release, optoelectronics dive into this technology.  Among of them, carriers with structures which can be ?exibly controlled are more useful since functional structure units can be assembled in layer-by-layer fashion, which is simplicity, chemical mildness, concealment, can achieve targeted drug delivery and so on.  In this review, we have discussed the advantage, development, influential factors and applications of LbL.  We have focused on reviewing the applications and perspective of nanoparticles, microgels and capsules were both fabricated via the LbL assembling at drug delivery.

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