药学学报, 2012, 47(6): 696-703
引用本文:
刘志华,孙晓波. 网络药理学:中医药现代化的新机遇[J]. 药学学报, 2012, 47(6): 696-703.
LIU Zhi-hua, SUN Xiao-bo . Network pharmacology: new opportunity for the modernization of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2012, 47(6): 696-703.

网络药理学:中医药现代化的新机遇
刘志华*, 孙晓波
(中国医学科学院、北京协和医学院药用植物研究所, 计算生物学与生物信息学研究中心, 北京 100193)
摘要:

中医药具有整体观和辨证论治的特点, 有着几千年丰富的临床经验, 在治疗复杂疾病方面显示出了良好的效果, 但由于中药及其复方具有多成分、多靶点、协同作用的特点, 使中医药的现代化发展遇到困阻近年来网络药理学在国际上兴起, 它融合系统生物学、多向药理学、计算生物学、网络分析等多学科的技术和内容, 进行-表型-基因-多层次网络的构建, 从整体的角度去探索药物与疾病间的关联性, 发现药物靶标, 指导新药研发。在方法学上, 网络药理学具有整体性、系统性的特点, 这与中医药整体观与辩证论治的原则不谋而合。本文对现阶段中医药现代化的机遇与挑战、网络药理学形成的概况及其在中医药研究中的初步应用做了简要综述, 主要介绍了网络药理学的原理及其在中医药现代化中的作用及应用。

关键词:   
Network pharmacology: new opportunity for the modernization of traditional Chinese medicine
Abstract:

Traditional Chinese medicine (TCM) with the characteristics of holistic view and treatment based on syndrome differentiation, has rich clinical experience thousands of years and demonstrates promising effects to cure complex disease.  However, due to the features of multi-component, multi-target and synergistic effect existed in TCM, the effective substances and mechanisms of action are not clear, the qualities of TCM are out of control, and scientific and correct assess system is waiting to be established.  The network pharmacology is a novel subject based on the construction of multi-layer networks of disease-phenotype-gene-drug to predict the drug targets in a holistic view, and promote efficiency of drug discovery.  Methodologically, network pharmacology integrated the notions of comprehensive research and systematic assessment which agree with the characteristics of holistic view and treatment based on syndrome differentiation in Chinese medicine.  Our paper reviewed the challenge and chance within the modernization of TCM, the concept and technology of network pharmacology, and its preliminary application in investigation of TCM.  The theoretical system of network pharmacology is emphasized, and the potential prospect of its application in modernization in TCM is focused.

Key words:   
收稿日期:
相关功能
PDF(622KB) Free
打印本文
0
作者相关文章