药学学报, 2012, 47(10): 1384-1388
引用本文:
陈盛君, 朱家壁, 祁小乐. 一种用于制剂学材料可压性评价的新方程研究[J]. 药学学报, 2012, 47(10): 1384-1388.
CHEN Sheng-jun, ZHU Jia-bi, QI Xiao-le. A new mathematical equation for the evaluation of the compression behavior of pharmaceutical materials[J]. Acta Pharmaceutica Sinica, 2012, 47(10): 1384-1388.

一种用于制剂学材料可压性评价的新方程研究
陈盛君1*, 朱家壁2, 祁小乐2
(1. 江阴天江药业有限公司, 江苏 江阴 214434; 2. 中国药科大学药剂教研室, 江苏 南京 210009)
摘要:

本文提出了一种新的压缩方程用于评价制剂粉体的可压性。该方程基于假设粉体可压缩体积随着压力的变化率与可压缩体积成正比。采用该模型方程将几种辅料的压缩数据进行非线性拟合, 达到了良好的拟合效果, 且方程中的参数可较好的反映粉末的压缩行为。该方程被证实对粉体压缩性的评价结果与川北方程一致。

关键词:   
A new mathematical equation for the evaluation of the compression behavior of pharmaceutical materials
Abstract:

A new mathematical equation characterizing the compression of pharmaceutical materials is presented.  This equation presumed that the rate of change of the compressible volume of powder with respect to the pressure is proportional to the compressible volume.  The new model provided a good fit to several model substances employing non-linear regression techniques.  The validity of the model had been verified with experimental results of various pharmaceutical powders according to the Akaikes informatics criterion (AIC) and the sum of squared deviations (SS).  The parameter of the new model might reflect quantitatively the fundamental compression behaviors of the powders.  It had demonstrated that the proposed model could well predict the compaction characteristics of solid particles like the Kawakita model.

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