药学学报, 2013, 48(3): 377-382
引用本文:
曾鹏,张勇,潘晨,贾琦,郭夫江,朱维良,李医明,陈凯先. 巴东过路黄酚类化学成分研究[J]. 药学学报, 2013, 48(3): 377-382.
ZENG Peng,ZHANG Yong,PAN Chen,JIA Qi,GUO Fujiang,ZHU Weiliang,LI Yiming,CHEN KX. Phenolic constituents from Lysimachia patungensis[J]. Acta Pharmaceutica Sinica, 2013, 48(3): 377-382.

巴东过路黄酚类化学成分研究
曾 鹏1†, 张 勇2†, 潘 晨1, 贾 琦1, 郭夫江1*, 朱维良2, 李医明1*, 陈凯先1, 2
(1. 上海中医药大学中药学院, 上海 201203; 2. 中国科学院上海药物研究所, 上海 201203)
摘要:

为了研究巴东过路黄的化学成分, 采用硅胶、ODSMCI以及Sephadex LH-20等柱色谱方法从巴东过路黄95% 乙醇提取物中分离得到12个酚类成分, 根据化合物的波谱数据分别鉴定为槲皮素-3-O-α-L-鼠李糖- 3'-O-α-L-鼠李糖苷 (1)、杨梅苷 (2)、槲皮苷 (3)、芦丁 (4)2-hydroxynaringenin-4'-O-glucopyranoside (5)、柚皮素-7-O-葡萄糖苷 (6)、芹糖甘草苷 (7)、甘草查尔酮B (8)tetrahydroxymethoxychalcone (9)、对羟基肉桂酸甲酯 (10)2, 4, 6-trihydroxyacetophenone 2-O-glucopyranoside (11) vaccihein A (12)。化合物1为新化合物, 化合物51112为首次从珍珠菜属植物中分离得到, 其余化合物为首次从该植物中分离得到。

关键词:   
Phenolic constituents from Lysimachia patungensis
Abstract:

To study the chemical constituents of Lysimachia patungensis Hand.-Mazz., silica gel column chromatography, reverse phase ODS column chromatography, MCI and Sephadex LH-20, were used to separate the 95% EtOH extract of the whole plant of Lysimachia patungensis Hand.-Mazz..  The structures of the isolated compounds have been established on the basis of chemical and NMR spectroscopic evidence as well as ESI-MS in some cases.  Twelve phenolic compounds were obtained and identified as quercetin-3, 3'-di-O-α- L-rhamnoside (1), myricetrin (2), quercitrin (3), rutin (4), 2-hydroxynaringenin-4'-O-glucopyranoside (5), naringenin 7-O-glucopyranoside (6), liquiritin apioside (7), licochalcone B (8), tetrahydroxymethoxy chalcone (9), methyl-p-coumarate (10), 2, 4, 6-trihydroxy acetophenone-2-O-glucopyranoside (11) and vaccihein A (12).  Among them, compound 1 is a new compound, and compounds 5, 11 and 12 are isolated from the genus Lysimachia L. for the first time, and the others are isolated from the plant for the first time.

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