药学学报, 2013, 48(6): 887-890
引用本文:
赵焕新, 聂田田, 郭焕杰, 白 虹. 光叶海桐根中的一个新三萜类化合物[J]. 药学学报, 2013, 48(6): 887-890.
ZHAO Huan-xin, NIE Tian-tian, GUO Huan-jie, BAI Hong. A new triterpenoid from Pittosporum glabratum Lindl.[J]. Acta Pharmaceutica Sinica, 2013, 48(6): 887-890.

光叶海桐根中的一个新三萜类化合物
赵焕新, 聂田田, 郭焕杰, 白 虹*
(山东省医学科学院药物研究所, 山东省罕少见病重点实验室, 山东 济南 250062)
摘要:

为了研究光叶海桐根 (Pittosporum glabratum Lindl.) 的化学成分, 利用硅胶柱色谱、葡聚糖凝胶LH-20柱色谱、反相开口柱色谱以及制备高效液相色谱等方法, 对其75% 乙醇提取物进行了分离和纯化, 共得到4个化合物。通过理化性质和波谱学方法分别鉴定为: 3β, 6β, 19α, 21α, 24-五羟基-12--28-齐墩果酸 (1)3-O-β- D-吡喃葡萄糖醛酸-28-O-β-D-吡喃葡萄糖泰国树脂酸 (2)3, 4, 5-三甲氧基苯-1-O-β-D-(5-O-丁香酰基)-呋喃芹糖- (1→6)-β-D-吡喃葡萄糖苷 (3) 3, 4, 5-三甲氧基苯-1-O-β-D-呋喃芹糖-(1→6)-β-D-吡喃葡萄糖苷 (4)。其中化合物1为新三萜类化合物, 化合物24为首次从该属植物中分离得到。

关键词:   
A new triterpenoid from Pittosporum glabratum Lindl.
Abstract:

The roots of Pittosporum glabratum Lindl. (Pittosporaceae) have been used as a folk medicine for the treatment of rheumatic arthritis, insomnia and hypertension.  Only a few chemical or biological studies on P. glabratum have been reported.  As part of our ongoing phytochemical research on this plant, four compounds were isolated.  Their structures were identified as 3β, 6β, 19α, 21α, 24-pentahydroxy-12-en-28-oleanolic acid (1), 3-O-β-D-glucuronopyranosyl-28-O-β-D-glucopyranosyl siaresinolic acid (2), 3, 4, 5-trimethoxyphenyl-1- O-β-D-(5-O-syringoyl)-apiofuranosyl-(16)-β-D-glucopyranoside (3) and 3, 4, 5-trimethoxyphenol-1-O-β-D- apiofuranosyl-(1→6)-β-D-glucopyranoside (4) on the basis of physical evidence and spectroscopic analysis.  Among them, compound 1 is a new triterpenoid, and compounds 24 are isolated from the genus Pittosporum for the first time.

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