药学学报, 2013, 48(6): 891-895
引用本文:
杨志钧, 杨 天, 罗敏玉, 夏 兴, 陈代杰, 钱秀萍. 一株刺盘孢属真菌中新的倍半萜及其细胞毒活性研究[J]. 药学学报, 2013, 48(6): 891-895.
YANG Zhi-jun, YANG Tian, LUO Min-yu, XIA Xing, CHEN Dai-jie, QIAN Xiu-ping. A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity[J]. Acta Pharmaceutica Sinica, 2013, 48(6): 891-895.

一株刺盘孢属真菌中新的倍半萜及其细胞毒活性研究
杨志钧1, 杨 天1, 罗敏玉2, 夏 兴1, 陈代杰1, 钱秀萍1*
(1. 上海交通大学药学院, 上海 200040; 2. 上海来益生物药物研究开发中心, 上海 200240)
摘要:

为了研究刺盘孢属真菌的大米发酵产物的细胞毒活性成分, 对其进行了化学研究和细胞毒活性分析。从其乙酸乙酯浸提部分分离得到4个化合物, 经波谱数据分析, 鉴定为新的倍半萜collectotriol (1) 和已知化合物isoaltenuene (2)altenuene (3) 4, 10-二甲氧基链格孢酚 (4)。细胞毒活性表明, 化合物14对肺癌细胞A549、乳腺癌细胞MDA-MB-231和肝癌细胞PANC-1有一定的细胞毒活性; 化合物4会使PANC-1细胞膨大而死亡, IC50 (60.2 μg·mL−1) 浓度下未能诱导细胞凋亡。

关键词:   
A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity
Abstract:

A novel sesquiterpenoid (1) and three known compounds identified as isoaltenuene (2), altenuene (3), and alternariol 4, 10-O-dimethyl ether (4), were isolated in our investigation of the cytotoxic constituents from solid cultures of the endophytic fungus Colletotrichum sp.  The structures of these compounds were elucidated through spectroscopic data analysis.  All compounds exhibited cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1.  Compound 4 could induce the PANC-1 cells inflation or death, but couldn’t induce apoptosis at the IC50 of 60.2 μg·mL−1.

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