药学学报, 2013, 48(7): 965-970
引用本文:
武玉洁,方莲花,杜冠华. 心肌缺血预适应和后适应研究进展及临床应用[J]. 药学学报, 2013, 48(7): 965-970.
WU Yu-jie, FANG Lian-hua, DU Guan-hua. Advance in the study of myocardial ischemic preconditioning and postconditioning and the clinical applications[J]. Acta Pharmaceutica Sinica, 2013, 48(7): 965-970.

心肌缺血预适应和后适应研究进展及临床应用
武玉洁1, 方莲花1, 2*, 杜冠华1, 2*
(中国医学科学院、北京协和医学院药物研究所, 1. 药物靶点研究与新药筛选北京市重点实验室, 2. 天然药物活性物质与功能国家重点实验室, 北京 100050)
摘要:

心肌缺血预适应和后适应均能缩小心肌梗死面积, 改善心肌收缩力, 保护冠状动脉内皮和心肌细胞的超微结构, 降低心律失常发生率。临床已证实这两种方法对心肌保护的安全性和有效性, 本文对近年来缺血预适应和后适应在心肌缺血再灌注损伤中保护机制及临床研究文献进行综述, 为寻找预防和治疗缺血性心脏病策略提供理论依据。

关键词:   
Advance in the study of myocardial ischemic preconditioning and postconditioning and the clinical applications
Abstract:

Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, protect coronary endothelial and myocardial cell ultrastructure, as well as reduce the incidence of arrhythmias.  Clinical practice has confirmed the safety and efficacy of these two methods of myocardial protection.  This paper reviewed about ischemic preconditioning and postconditioning protection mechanisms in myocardial ischemia reperfusion injury and clinical research literatures in recent years, to provide a theoretical basis for finding new treatment strategies on the prevention and treatment of ischemic cardiomyopathy.

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