药学学报, 2009, 44(3): 264-269
引用本文:
陈晓光 张 翼. 抗肿瘤药物研究新靶点及研究进展——极光激酶和Pin1[J]. 药学学报, 2009, 44(3): 264-269.
CHEN Xiao-Guang, Zhang- Yi. Recent advance in the study of novel anti-tumor targets and drugs —aurora kinase and Pin1[J]. Acta Pharmaceutica Sinica, 2009, 44(3): 264-269.

抗肿瘤药物研究新靶点及研究进展——极光激酶和Pin1
陈晓光*, 张 翼
(中国医学科学院、北京协和医学院药物研究所, 北京 100050)
摘要:

恶性肿瘤是威胁人类生命健康的重大难治性疾病,人类在恶性肿瘤的治疗过程中经历了漫长的历史变迁。抗肿瘤药物是重要的治疗手段之一,随着研究的深入与科学技术的发展,抗肿瘤药物随着新靶点的发现而不断进步。大量新的抗肿瘤药物靶点如极光激酶和Pin1的发现以及它们与肿瘤发生发展关系的阐明为寻找有效的抗肿瘤药物,更好地治疗肿瘤奠定了基础,目前已经有针对新靶点的药物进入临床前或临床研究。

关键词:   
Recent advance in the study of novel anti-tumor targets and drugs —aurora kinase and Pin1
Abstract:

Malignant tumor, one of the most refractory diseases, plays a threaten role in human health, the therapy and research on malignant tumor have taken a long way to go.  The anti-tumor drugs which are the   essential therapy strategies upgrade with the development of new anti-tumor targets and the research on tumor pathogenesis.  Aurora kinase and Pin1, the novel anti-tumor targets, maintain the important relationship with tumor.  Many new compounds designed on these targets have excellent anti-tumor effects and also enter into phase I or phase II clinical trial.

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