药学学报, 2009, 44(5): 443-448
引用本文:
应剑,吕扬,杜冠华. 固体药物无定型状态的研究进展[J]. 药学学报, 2009, 44(5): 443-448.
YING Jian, Lv-Yang, Du-Guan-Hua. Progress in the research of amorphous pharmaceuticals[J]. Acta Pharmaceutica Sinica, 2009, 44(5): 443-448.

固体药物无定型状态的研究进展
摘要:

固体药物的无定型状态是药物分子排列的无序状态,这种物质状态可能增加药物的生物利用度,促进药物的快速吸收,同时也有可能改变药物的疗效。同一药物的无定型态制剂,在不同的制备工艺下,也可表现出不同的性质。因此,固体药物的无定型状态是新药研发过程中重要的研究内容。然而无定型状态固体物质的稳定性一般较差,有些无定型状态的药物甚至具有潜在的不良反应,成为阻碍药物无定型态应用的障碍。本文主要介绍近年来在药物无定型状态研究领域的进展,探讨影响无定型状态的药物作用的可能因素,分析无定型在药物研发中的应用前景。

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Progress in the research of amorphous pharmaceuticals
Abstract:

Amorphous is a special physical state of solid compounds that the positions of the molecules or atoms have no long-range order.  Sometimes amorphous compounds have better bioavailability, or achieve   ultra-fast absorption in situation of acute and intermittent symptoms than that of morphous compounds, thus change drug efficacy.  Besides, different pharmaceutical preparing methods can lead to different characters.  Research of amorphous compounds has been a hotspot, both in research field and industry world.  However, there are challenges as amorphous compounds could be unstable; unexpected adverse drug reactions may also exist.  In this review, recent progress in the research of amorphous pharmaceutical compounds both in the research field and the pharmaceutical industry is reviewed.  Factors which can influence the efficacy of amorphous pharmaceuticals are summarized.  The prospect of amorphous techniques is also discussed.

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