药学学报, 2009, 44(1): 11-18
引用本文:
胡立宏 徐吉庆. 基于经典天然产物的药物发现研究[J]. 药学学报, 2009, 44(1): 11-18.
HU Li-Hong, Xu-Ji-Qiang. Drug discovery based on classic natural products[J]. Acta Pharmaceutica Sinica, 2009, 44(1): 11-18.

基于经典天然产物的药物发现研究
(中国科学院上海药物研究所, 上海 201203)
摘要:

利用现代细胞生物学、分子生物学技术开展经典天然产物的分子机制研究, 建立合适的体外活性评价模型系统, 然后通过药物化学技术进一步研究其结构与活性、结构与毒性、结构与ADME (absorption, distribution, metabolism and excretion) 性质的关系, 是我国发现具有自主知识产权新药的一条有效途径。

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Drug discovery based on classic natural products
Abstract:

We think the strategy of classic natural product-based drug discovery will be an effective way for us to develop new drugs with independent intellectual property.  The strategy includes: to study the molecular mechanism of action of classic natural product with chemical genetics and chemical biology approaches firstly; then establish the proper in vitro bioassay or bioassay system based on its molecular mechanism for their pharmacodynamic evaluation; finally, study their structure-activity, structure-toxicity and structure-ADME properties with medicinal chemistry.

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