药学学报, 2014, 49(8): 1089-1096
引用本文:
玄玲玲, 侯琦. AMPK与肺部炎症研究进展[J]. 药学学报, 2014, 49(8): 1089-1096.
XUAN Ling-ling, HOU Qi. Recent advances in the study of AMPK and inflammatory pulmonary disease[J]. Acta Pharmaceutica Sinica, 2014, 49(8): 1089-1096.

AMPK与肺部炎症研究进展
玄玲玲, 侯琦
中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050
摘要:
腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK) 是细胞的能量调节器,在维持机体能量代谢平衡中发挥重要作用。最近研究表明,AMPK能通过调节氧化应激、抗炎等途径减轻哮喘、慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)、肺部感染性疾病、肺纤维化的肺组织损伤。AMPK主要通过下游靶分子如沉默信息调节因子1(sirtuin1,SIRT1)、过氧化物酶体增殖物激活受体γ共激活因子-1α(peroxisome proliferator-activated receptor γ coactivator-1α,PGC-1α)、p53和FoxO转录因子3a(forkhead box O3a,FoxO3a) 等抑制肺部炎症反应。因此,AMPK及其信号通路有望成为治疗肺部炎症疾病的药理学靶点。本文就AMPK与肺部炎症疾病的关系进行综述。
关键词:    AMPK      炎症      氧化应激      哮喘      COPD      肺部感染性疾病      肺纤维化     
Recent advances in the study of AMPK and inflammatory pulmonary disease
XUAN Ling-ling, HOU Qi
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
AMP-activated protein kinase (AMPK) is an important regulator of cellular energy homeostasis. Recent studies demonstrated that AMPK is a novel signaling molecule modulating inflammatory responses and oxidative stress which are involved in inflammatory pulmonary diseases, such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary infectious diseases and pulmonary fibrosis. AMPK attenuates inflammatory lung injury by phosphorylating its downstream targets, such as sirtuin1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-lα), p53 and forkhead box O3a (FoxO3a). This review summarized the relationship between AMPK and the development of inflammatory pulmonary diseases.
Key words:    AMPK    inflammation    oxidative stress    asthma    COPD    pulmonary infectious diseases    pulmonary fibrosis   
收稿日期: 2014-02-27
基金项目: 十二五综合大平台-药效学评价(37008);医科院留学回国择优项目经费-哮喘炎症
通讯作者: 侯琦 Tel:86-10-63165191,Fax:86-10-63017755,E-mail:houq@imm.ac.cn
Email: houq@imm.ac.cn
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