药学学报, 2014, 49(8): 1181-1187
引用本文:
侯岩龙, 李鹤然, 高亚男, 王岩, 王齐放, 徐璐, 刘振云, 陈洪涛, 李三鸣. 常用亲水凝胶辅料的流变学性质研究[J]. 药学学报, 2014, 49(8): 1181-1187.
HOU Yan-long, LI He-ran, GAO Ya-nan, WANG Yan, WANG Qi-fang, XU Lu, LIU Zhen-yun, CHEN Hong-tao, LI San-ming. The rheology properties of common hydrophilic gel excipients[J]. Acta Pharmaceutica Sinica, 2014, 49(8): 1181-1187.

常用亲水凝胶辅料的流变学性质研究
侯岩龙, 李鹤然, 高亚男, 王岩, 王齐放, 徐璐, 刘振云, 陈洪涛, 李三鸣
沈阳药科大学药学院, 辽宁 沈阳 110016
摘要:
本文以黏度为指标考察卡波姆(Carbopol) 等常见亲水凝胶辅料的流变学性质。分别采用旋转法和落球法测定黏度;以黏度对数(lnη) 对浓度线性拟合,根据斜率考察辅料黏度与浓度的关系;通过阿伦尼乌斯(Arrhenius) 公式计算辅料的黏流活化能(Eη),考察辅料黏度与温度关系。结果表明,旋转法与落球法测定黏度的结果一致;瓜尔胶(guargum,GG) 和羟丙基甲基纤维素(hydroxypropyl methylcellulose,HPMC) 等溶液黏度受浓度影响较大(k > 5),聚乙烯吡咯烷酮K30(polyvinylpyrrolidone-K30,PVP-K30) 和聚乙二醇6000(polyethy-leneglycol,PEG6000) 等受到影响较小(k < 0.2);不同辅料的黏流活化能比较相近,介于30~40 kJ·mol-1。因此溶液流变学性质的研究可对辅料的应用提供依据,为辅料结构、性质与功能之间关系的研究奠定了基础。
关键词:    凝胶辅料      流变学性质      黏度      落球法      旋转法      黏流活化能     
The rheology properties of common hydrophilic gel excipients
HOU Yan-long, LI He-ran, GAO Ya-nan, WANG Yan, WANG Qi-fang, XU Lu, LIU Zhen-yun, CHEN Hong-tao, LI San-ming
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Abstract:
To investigate rheological properties of common hydrophilic gel excipients such as Carbopol based on viscosity, the viscosity was determined by rotation method and falling-ball method. Linear regression was made between lnη and concentration, the slope of which was used to explore the relation between viscosity and concentration of different excipients. The viscosity flow active energy (Eη) was calculated according to Arrhenius equation and was used to investigate the relation between viscosity and temperature of different excipients. The results showed that viscosities measured by two methods were consistent. Concentration of guargum (GG) and hydroxypropylmethyl cellulose (HPMC) solution had a great influence on the viscosity, k > 5; while concentration of polyvinylpyrrolidone-K30 (PVP-K30) and polyethylene glycol 6000 (PEG6000) exerted a less effect on viscosity, k < 0.2; viscosity flow active energy of different excipients were close, which ranged from 30 to 40 kJ·mol-1. Therefore, rheological properties study could provide the basis for application of excipients and establish a foundation for the research of relation between excipients structure, property and function.
Key words:    gel excipient    rheological property    viscosity    falling-ball method    rotation method    viscosity flow active energy   
收稿日期: 2014-03-27
通讯作者: 李三鸣 Tel/Fax:86-24-23986258,E-mail:li_sanming@126.com
Email: li_sanming@126.com
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