药学学报, 2014, 49(10): 1372-1376
耿海局, 罗焕敏. 金属与阿尔茨海默病的研究进展[J]. 药学学报, 2014, 49(10): 1372-1376.
GENG Gelite, LUO Huan-min. The research progress of metals correlated to Alzheimer’s disease[J]. Acta Pharmaceutica Sinica, 2014, 49(10): 1372-1376.

耿海局1, 罗焕敏1,2
1. 暨南大学医学院, 广东 广州 510632;
2. 暨南大学脑科学研究所, 广东 广州 510632
阿尔茨海默病(Alzheimer's disease,AD)为一种神经退行性疾病,是导致成年人痴呆最常见的原因之一。人们对于该病的研究虽历时数百余年,其中Aβ学说、tau学说在AD中的作用得到广泛认可,但是有关AD的具体发病机制仍不十分清楚。可以明确的是,AD是一种多因素引起的疾病,除了遗传、衰老和生活习惯外,环境因素也不容忽视,一些金属元素,如铜、铝、锌和铁等都可能与AD密切相关。本文就这些金属元素与AD的相关研究进行简要概述。
关键词:    阿尔茨海默病                             
The research progress of metals correlated to Alzheimer’s disease
GENG Gelite1, LUO Huan-min1,2
1. School of Medicine, Jinan University, Guangzhou 510632, China;
2. Institution for Brain Science, Jinan University, Guangzhou 510632, China
Alzheimer's disease (AD) is a kind of neurodegenerative diseases, the most common cause of dementia. Although AD has been studied more than 100 years and the Aβ and tau theory are most widely accepted among the theories achieved, yet it is not really clear what the mechanism related to AD works up to now. However, it is certain that AD is a kind of diseases resulting from multi-causes. Except for causes correlated with heredity, aging and life habits, environmental role is worth taking into consideration as well. Some metals, such as copper, aluminum, zinc and iron et al, can also have close relationship with AD. Now, we make an overview on the correlative researches in the field.
Key words:    Alzheimer’s disease    copper    aluminum    zinc    iron   
收稿日期: 2014-05-04
基金项目: 国家自然科学基金资助项目(81173037);国家973项目(2011CB707500);广东省科技计划项目(2012B050300018)
通讯作者: 罗焕敏,Tel/Fax:86-20-85228869,E-mail:tlhm@jnu.edu.cn
Email: tlhm@jnu.edu.cn
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耿海局  在本刊中的所有文章
罗焕敏  在本刊中的所有文章

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