药学学报, 2014, 49(10): 1387-1394
引用本文:
郝大程, 肖培根, 刘明, 彭勇, 何春年. 从药用亲缘学到药用基因组亲缘学:分子系统发育、进化与药物发现[J]. 药学学报, 2014, 49(10): 1387-1394.
HAO Da-cheng, XIAO Pei-gen, LIU Ming, PENG Yong, HE Chun-nian. Pharmaphylogeny vs. pharmacophylogenomics:molecular phylogeny, evolution and drug discovery[J]. Acta Pharmaceutica Sinica, 2014, 49(10): 1387-1394.

从药用亲缘学到药用基因组亲缘学:分子系统发育、进化与药物发现
郝大程1, 肖培根2, 刘明1, 彭勇2, 何春年2
1. 大连交通大学生物技术研究所, 环境化工学院, 辽宁 大连 116028;
2. 中国医学科学院、北京协和医学院药用植物研究所, 北京 100193
摘要:
近年随着高通量测序技术的迅猛发展,生物系统发育研究中开始采用基因组数据,因此出现一些新术语,如系统发育基因组学(phylogenomics,基因组系统学/基因组亲缘学)、药用基因组亲缘学(pharmacophy- logenomics)、转录组亲缘学(phylotranscriptomics)等。系统发育基因组学是进化和基因组学的交叉学科,是将基因组数据用于进化关系重建的综合分析;药用亲缘学研究药用生物(特别是药用植物)的生物亲缘关系、化学成分和疗效(传统疗效和药理活性)间的相关性;系统发育基因组学方法可用于药物发现和开发的相关问题研究,在组学水平拓展了药用亲缘学的领域,由此衍生出药用基因组亲缘学。系统学(亲缘学)是生命科学各分支和交叉学科的根基所在,在生药学和药用生物学等药学相关领域起到提纲挈领的作用。在此对与药用亲缘学(pharmaphylogeny)密切相关的若干术语做一简要辨析。
关键词:    药用亲缘学      药用基因组亲缘学      分子系统发育      进化      药物发现     
Pharmaphylogeny vs. pharmacophylogenomics:molecular phylogeny, evolution and drug discovery
HAO Da-cheng1, XIAO Pei-gen2, LIU Ming1, PENG Yong2, HE Chun-nian2
1. Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China;
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Abstract:
With the surge of high-throughput sequencing technology, it is becoming popular to perform the phylogenetic study based on genomic data. A bundle of new terms is emerging, such as phylogenomics, pharmacophylogenomics and phylotranscriptomics, which are somewhat overlapping with pharmaphylogeny. Phylogenomics is the crossing of evolutionary biology and genomics, in which genome data are utilized for evolutionary reconstructions. Pharmaphylogeny, advocated by Prof. Pei-gen Xiao since 1980s, focuses on the phylogenetic relationship of medicinal plants and is thus nurtured by molecular phylogeny, chemotaxonomy and bioactivity studies. Phylogenomics can be integrated into the flow chart of drug discovery and development, and extend the field of pharmaphylogeny at the omic level, thus the concept of pharmacophylogenomics could be redefined. This review gives a brief analysis of the association and the distinguished feature of the pharmaphylogeny related terms, in the context of plant-based drug discovery and sustainable utilization of pharmaceutical resource.
Key words:    pharmaphylogeny    pharmacophylogenomics    molecular phylogeny    evolution    drug discovery   
收稿日期: 2014-04-21
基金项目: 科技部国家支撑计划(2012BAI29B01)
通讯作者: 郝大程,Tel:86-411-84572552,E-mail:hao@djtu.edu.cn;肖培根,E-mail:xiaopg@public.bta.net.cn
Email: hao@djtu.edu.cn;xiaopg@public.bta.net.cn
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