药学学报, 2014, 49(10): 1433-1437
引用本文:
张勇, 高媛媛, 贾琦, 郭夫江, 李波, 徐志建, 李医明, 朱维良, 陈凯先. 毛裂蜂斗菜中两个新的倍半萜硫酸酯[J]. 药学学报, 2014, 49(10): 1433-1437.
ZHANG Yong, GAO Yuan-yuan, JIA Qi, GUO Fu-jiang, LI Bo, XU Zhi-jian, LI Yi-ming, ZHU Wei-liang, CHEN Kai-xian. Two new sulfated sesquiterpenoids from Petasites tricholobus[J]. Acta Pharmaceutica Sinica, 2014, 49(10): 1433-1437.

毛裂蜂斗菜中两个新的倍半萜硫酸酯
张勇1, 高媛媛2, 贾琦2, 郭夫江2, 李波1, 徐志建1, 李医明2, 朱维良1, 陈凯先1,2
1. 中国科学院上海药物研究所受体结构与功能重点实验室, 上海 201203;
2. 上海中医药大学中药学院中药化学教研室, 上海 201203
摘要:
从毛裂蜂斗菜全草中分离得到两个新的倍半萜硫酸酯类化合物megastigman-7-ene-3,5,6,9-tetrol-3-O-β-D-6'-sulfonated-glucopyranoside(1)、3-O-β-D-6'-sulfonated-glucopyranosyl-6-(3-oxo-2-butenylidenyl)-1,1,5- trimethylcyclohexan-5-ol(2)和一个已知化合物icariside B1(3)。其中化合物icariside B1(3)为首次从蜂斗菜属植物中分离得到。通过化学和波谱等方法对上述结构进行了鉴定。此外,还测定了3个化合物对4种肿瘤细胞(HepG2、HCT 116、H460和MCF7)的细胞毒活性。
关键词:    毛裂蜂斗菜      菊科      倍半萜硫酸酯     
Two new sulfated sesquiterpenoids from Petasites tricholobus
ZHANG Yong1, GAO Yuan-yuan2, JIA Qi2, GUO Fu-jiang2, LI Bo1, XU Zhi-jian1, LI Yi-ming2, ZHU Wei-liang1, CHEN Kai-xian1,2
1. Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
2. Department of Phytochemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract:
Two new sulfated sesquiterpenoids, megastigman-7-ene-3, 5, 6, 9-tetrol-3-O-β-D-6'-sulfonated- glucopyranoside (1) and 3-O-β-D-6'-sulfonated-glucopyranosyl-6-(3-oxo-2-butenylidenyl)-1, 1, 5-trimethylcy-clohexan-5-ol (2), along with one known sesquitepenoid compound icariside B1 (3) were isolated from the whole herb of Petasites tricholobus Franch. Their structures were identified by their chemical and spectroscopic characters. All obtained compounds were tested for their cytotoxicity against four cancer cell lines.
Key words:    Petasites tricholobus    Asteraceae    sulfated sesquiterpenoids   
收稿日期: 2014-03-28
通讯作者: 李医明,Tel:86-21-51322191,Fax:86-21-51322193,E-mail:ymlius@163.com;朱维良,Tel:86-21-50806600-1205,Fax:86-21-50807188,E-mail:wlzhu@mail.shcnc.ac.cn
Email: ymlius@163.com;wlzhu@mail.shcnc.ac.cn
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