药学学报, 2014, 49(10): 1475-1478
引用本文:
耿晶, 张字城, 张海波, 李新霞, 陈坚. 光纤传感过程分析测定蒜氨酸固有溶出率[J]. 药学学报, 2014, 49(10): 1475-1478.
GENG Jing, ZHANG Zi-cheng, ZHANG Hai-bo, LI Xin-xia, CHEN Jian. Determination of intrinsic alliin dissolution rates with fiber-optic sensing process analysis[J]. Acta Pharmaceutica Sinica, 2014, 49(10): 1475-1478.

光纤传感过程分析测定蒜氨酸固有溶出率
耿晶1, 张字城1, 张海波1, 李新霞1, 陈坚2
1. 新疆医科大学药学院, 新疆 乌鲁木齐 830011;
2. 新疆埃乐欣药业有限公司, 新疆 乌鲁木齐 830013
摘要:
关键词:    蒜氨酸      光纤传感      固有溶出率      转盘法      定盘法     
Determination of intrinsic alliin dissolution rates with fiber-optic sensing process analysis
GENG Jing1, ZHANG Zi-cheng1, ZHANG Hai-bo1, LI Xin-xia1, CHEN Jian2
1. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China;
2. Xingjiang Ailexin Pharm. Co., Ltd., Urumqi 830013, China
Abstract:
The apparatus for intrinsic dissolution test recorded in United States Pharmacopeia(USP)integrating with fiber-optic drug dissolution test system(FODT)were used to real-time monitor intrinsic dissolution processes of alliin in four media which were water,solution of HCl with pH 1.2,buffer solution of acetate with pH 4.5,and buffer solution of phosphate with pH 6.8. The intrinsic dissolution rate(IDR)and the similarity factor(f2)of two intrinsic dissolution curves with two apparatuses were calculated. The IDR values of alliin with rotating disk system were 28.13,33.55,28.38 and 30.95 mg·cm-2·min-1 in four media,respectively. And the IDR values of alliin with stationary disk system were 44.16,47.07,45.11 and 51.34 mg·cm-2·min-1,respectively. The similarity factors were 56.42,50.75,40.30 and 40.64,respectively. The results showed that the intrinsic alliin dissolution rates were much greater than 1 mg·cm-2·min-1. It inferred that alliin dissolution would not be the rate limiting step to absorption.
Key words:    alliin    fiber-optic sensing    intrinsic dissolution    rotating disk system    stationary disk system   
收稿日期: 2014-03-17
基金项目: 国家自然科学基金资助项目(81260486)
通讯作者: 李新霞,Tel/Fax:86-991-4365034,E-mail:lxx6668@163.com
Email: lxx6668@163.com
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参考文献:
[1] Amidon GE, Higuchi WI, Ho NF. Theoretical and experimental studies of transport of micelle-solubilized solutes [J]. J Pharm Sci, 1982, 71: 77-84.
[2] Yu LX, Carlin AS, Amidon GL, et al. Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs [J]. Int J Pharm, 2004, 270: 221-227.
[3] Jinno J, Oh DM, Crison JR, et al. Dissolution of ionizable water-insoluble drugs: the combined effect of pH and surfactant [J]. J Pharm Sci, 2000, 89: 268-274.
[4] Dahlan R, McDonald C, Sunderland VB. Solubilities and intrinsic dissolution rates of sulphamethoxazole and trimethoprim [J]. J Pharm Pharmacol, 1987, 39: 246-251.
[5] Hanson R, Gray V. Handbook of Dissolution Testing [M]. 3rd ed. Beijing: Chinese Medical Science and Technology Press, 2007: 19.
[6] Viegas TX, Curatella RU, Winkle LL, et al. Measurement [7] Viscomi GC, Campana M, Braga D, et al. Polymorphous forms of rifaximin, preparation and application thereof used in pharmaceutical preparation: CN, 101260114B [P]. 2012-11-28.
[8] Chen JX, Guo Z, Li HY, et al. Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel [J]. Acta Pharm Sin (药学学报), 2013, 48: 1156-1163.
[9] The United States Pharmacopeia Convention. United States Pharmacopeia/National Formulary [S]. 2011 ed. Vol. 2. Baltimore: United Book Press, 2011.
[10] The European Pharmacopoeia Commission. European Pharmacopoeia [S]. 7th ed. Strasbourg: European Directorate for the Quality of Medicines, Council of Europe, 2010.
[11] The British Pharmacopoeia Commission. British Pharmacopoeia [S]. 2010 ed. London: The Stationary Office, 2010.
[12] Zhang QM, Ge JH, Chen J. Continuous in situ monitoring of the dissolution rate of solid pharmaceutical preparations using a multiple channel fiber-optic chemical sensor [J]. Acta Pharm Sin (药学学报), 2003, 38: 294-297.
[13] Li XX, Wang Y, Xu PP, et al. Effects of temperature and wavelength choice on in-situ dissolution test of cimetidine tablets [J]. J Pharm Anal, 2013, 3:71-74.
[14] Li XX, Wang YW, Wang Y, et al. A fiber optic chemical sensor system for on-line monitoring the drug dissolution of Rifampicin [J]. Acta Pharm Sin (药学学报), 2002, 37: 721-723.
[15] Zhu B, Xing JF, Chen J, et al. Continuous in situ monitor-ing of the dissolution rate of metronidazole tablets using a fiber-optic chemical sensor [J]. Acta Pharm Sin (药学学报), 1994, 29: 369-374.
[16] Jin L, Li L, Li XX, et al. Rapid analysis of metronidazole tablets by optic-fiber sensing technologies and the similarity of ultraviolet spectra [J]. Acta Pharm Sin (药学学报), 2011, 46: 203-206.
[17] Nie K, Li L, Li XX, et al. Monitoring ambroxol hydrochloride sustained-release tablets release by fiber-optic drug dissolution in situ test system [J]. Dissolut Technol, 2009, 16: 14-17.
[18] Issa MG, Ferraz HG. Intrinsic dissolution as a tool for evaluating drug solubility in accordance with the biopharmaceutics classification system [J]. Dissolut Technol, 2011, 18: 6-13.
[19] Shah VP, Tsong Y, Sathe P, et al. In vitro dissolution pro-file comparison-statistics and analysis of the similarity factor, f2 [J]. Pharm Res, 1998, 15: 889-896.