药学学报, 2014, 49(12): 1625-1630
引用本文:
侯碧玉, 李莉, 张莉, 杜冠华. SIRT1在糖尿病肾病防治中的作用[J]. 药学学报, 2014, 49(12): 1625-1630.
HOU Bi-yu, LI Li, ZHANG Li, DU Guan-hua. The role of SIRT1 in the treatment of diabetic nephropathy[J]. Acta Pharmaceutica Sinica, 2014, 49(12): 1625-1630.

SIRT1在糖尿病肾病防治中的作用
侯碧玉, 李莉, 张莉, 杜冠华
中国医学科学院、北京协和医学院药物研究所国家药物筛选中心, 药物靶点研究和新药筛选北京市重点实验室, 北京 100050
摘要:
随着糖尿病肾病发病率日益升高, 寻找治疗糖尿病肾病的新靶点已成为世界范围内的研究热点.SIRT1即沉默信息调节因子, 为去乙酰化酶家族成员之一, 参与细胞衰老、代谢、凋亡等生理和病理过程.近十年研究表明, SIRT1可以通过促进高糖环境下肾脏细胞能量稳态重建、调节糖尿病肾病发病过程中的氧化应激状态, 抵抗肾脏细胞凋亡, 抑制肾脏炎症反应, 改善肾脏纤维化等作用, 阻止糖尿病肾病发生和发展, 成为糖尿病肾病防治潜在的新靶点.
关键词:    糖尿病肾病      SIRT1      药物靶点     
The role of SIRT1 in the treatment of diabetic nephropathy
HOU Bi-yu, LI Li, ZHANG Li, DU Guan-hua
Beijing City Key Laboratory of Drug Target and Screening Research, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Diabetic nephropathy presents an increasing trend worldwide. It has been an attractive area to find novel targets for the treatment of diabetic nephropathy. SIRT1 (Sirtuin 1), a member of deacetylation enzymes, regulates cell senescence, metabolism, and apoptosis. In last ten years, lots of studies showed that SIRT1 exerts a protective effect in the progression of the diabetic nephropathy by promoting reconstruction of energy homeostasis, modulating cell redox state, resisting cell apoptosis, inhibiting inflammation and ameliorating renal fibrosis. SIRT1 has become a potential new target for the treatment of diabetic nephropathy.
Key words:    diabetic nephropathy    SIRT1    drug target   
收稿日期: 2014-05-29
基金项目: 国家自然科学基金资助项目(81102492,81102444);基本科研业务费(2013ZD02,2014CX05).
通讯作者: 张莉, 杜冠华
Email: zhangli@imm.ac.cn;dugh@imm.ac.cn
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