药学学报, 2014, 49(12): 1689-1693
引用本文:
彭文文, 宋卫武, 黄茂波, 曾广智, 谭宁华. 小叶臭黄皮中12个苯环衍生物[J]. 药学学报, 2014, 49(12): 1689-1693.
PENG Wen-wen, SONG Wei-wu, HUANG Mao-bo, ZENG Guang-zhi, TAN Ning-hua. Twelve benzene derivatives from Clausena excavata [J]. Acta Pharmaceutica Sinica, 2014, 49(12): 1689-1693.

小叶臭黄皮中12个苯环衍生物
彭文文1,2,3, 宋卫武2, 黄茂波2, 曾广智2, 谭宁华2
1. 江西农业大学江西省天然产物与功能食品重点实验室, 江西 南昌 330045;
2. 中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201;
3. 江西农业大学农学院, 江西 南昌 330045
摘要:
对小叶臭黄皮 (Clausena excavata) 根、茎和叶部位进行了化学成分研究, 经过一系列正相和反相色谱柱和高效液相色谱等现代分离技术, 分离得到12个苯环衍生物 (112), 并通过MS、NMR、IR等波谱学方法对这些化合物进行结构鉴定, 其中 (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1) 为一个新化合物, 化合物34为两个新天然产物, 化合物581012均为首次从该植物中分离得到.测定了化合物1对A549、HeLa和BGC-823的细胞毒活性及其对Candida albicansStaphylococcus aureus的抑菌活性, 结果显示化合物1没有细胞毒和抑菌活性.
关键词:    小叶臭黄皮      苯乙醇      苯环衍生物     
Twelve benzene derivatives from Clausena excavata
PENG Wen-wen1,2,3, SONG Wei-wu2, HUANG Mao-bo2, ZENG Guang-zhi2, TAN Ning-hua2
1. Jiangxi Key Laboratory of Natural Products and Functional Food, Jiangxi Agricultural University, Nanchang 330045, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3. College of Agriculture, Jiangxi Agricultural University, Nanchang 330045, China
Abstract:
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
Key words:    Clausena excavata    phenethalol    benzene derivatives   
收稿日期: 2014-06-11
基金项目: Project supported by the National New Drug Innovation Major Project of China (2011ZX09307-002-02) and the Natural Science Foundation of Yunnan Province (2012GA003).
通讯作者: 谭宁华
Email: nhtan@mail.kib.ac.cn
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