药学学报, 2014, 49(12): 1739-1742
引用本文:
吴杲, 吴汉斌, 蒋红. 虎杖苷的降尿酸作用及其机制研究[J]. 药学学报, 2014, 49(12): 1739-1742.
WU Gao, WU Han-bin, JIANG Hong. Anti-hyperuricemia effect and mechanism of polydatin in mice[J]. Acta Pharmaceutica Sinica, 2014, 49(12): 1739-1742.

虎杖苷的降尿酸作用及其机制研究
吴杲1, 吴汉斌2, 蒋红1
1. 解放军第411医院, 上海 200081;
2. 同济大学附属东方医院, 上海 200120
摘要:
关键词:    虎杖苷      高尿酸血症      尿酸转运体蛋白1      阴离子转运蛋白     
Anti-hyperuricemia effect and mechanism of polydatin in mice
WU Gao1, WU Han-bin2, JIANG Hong1
1. The 411 Hospital of PLA, Shanghai 200081, China;
2. Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China
Abstract:
Hyperuricemia mice model was established with uricase inhibitor (potassium oxonate) and uric acids in serum were observed. Polydatin (5, 10, 20 mg·kg-1) and benzbromarone (16.7 mg·kg-1) were given ig for 7 d in mice. Kidney tissues were used to detect gene contents of urate anion transporter 1 (URAT1), organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) by real-time-PCR. The results showed that polydatin and benzbromarone can significantly reduce uric acid in blood of hyperuricemia mice (P < 0.05), compared with the model group. URAT1, OAT1 and OAT3 contents of the kidney in hyperuricemia mice changed significantly (P < 0.05), compared with the blank group. Polydatin can significantly inhibit the changing trends in these genes induced by potassium oxonate in a dose-dependent manner, the difference was significant (P < 0.05), compared with the model group. Those indicated that polysatin could reduce the level of the serum uric acid through promoting uric acid excretion.
Key words:    polydatin    hyperuricemia    urate transporter 1    organic anion transporter    
收稿日期: 2014-05-28
基金项目: 上海市虹口区卫生局支持课题(虹卫20130426).
通讯作者: 吴汉斌
Email: hanbiwu2000@outlook.com
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