药学学报, 2016, 51(10): 1595-1599
引用本文:
袁旭江, 张平, 李春阳, 霍务贞, 鲁湘鄂, 吴燕红. 毛鸡骨草叶中一个新的吐昔酰胺类成分[J]. 药学学报, 2016, 51(10): 1595-1599.
YUAN Xu-jiang, ZHANG Ping, LI Chun-yang, HUO Wu-zhen, LU Xiang-e, WU Yan-hong. One new truxillic amide compound from Abrus mollis leaves[J]. Acta Pharmaceutica Sinica, 2016, 51(10): 1595-1599.

毛鸡骨草叶中一个新的吐昔酰胺类成分
袁旭江, 张平, 李春阳, 霍务贞, 鲁湘鄂, 吴燕红
广东药科大学中药开发研究所, 国家中医药管理局中药制剂三级实验室, 广东 广州 510006
摘要:
毛鸡骨草(Abrus mollis Hance)叶采用水醇提取,不同有机溶剂萃取,获得正丁醇部位,利用各种柱色谱技术进行分离纯化,理化性质结合UV、MS、TLC、HPLC和NMR等波谱技术鉴定出6个化合物,分别为:葫芦巴碱(1)、脯氨酸(2)、丙氨酸酐(3)、顺式-N-(4-羟基桂皮酰)酪氨酸(4)、反式-N-(4-羟基桂皮酰)酪氨酸(5)和鸡骨草丙素(6)。化合物6为新化合物,化合物14均是首次从该植物中分离得到。
关键词:    毛鸡骨草      化学成分      鸡骨草丙素      酰胺类     
One new truxillic amide compound from Abrus mollis leaves
YUAN Xu-jiang, ZHANG Ping, LI Chun-yang, HUO Wu-zhen, LU Xiang-e, WU Yan-hong
Research and Development Institute of Chinese Materia Medica, Guangdong Pharmaceutical University/Class III Laboratory of Modern Chinese Medicine Preparation, State Administration of Traditional Chinese Medicine of the P. R. C., Guangzhou 510006, China
Abstract:
The butanol extract part was extracted and isolated with water, alcohol and different organic solvents from Abrus mollis leaves. 6 compounds were isolated and purified using various column chromatographies and identified with the spectral techniques such as UV, MS, TLC, HPLC and NMR. The structures of 6 compounds were trigonelline (1), praline (2), alanine anhydride (3), (Z)-N-(4-hydroxycinnamoyl)tyrosine (4), (E)-N-(4-hydroxycinnamoyl)tyrosine (5), and abrusamide C (6). Compound 6 is a new compound, and compounds 1-4 were isolated from the plant for the first time.
Key words:    Abrus mollis Hance    chemical constituent    abrusamide C    amide   
收稿日期: 2016-06-06
DOI: 10.16438/j.0513-4870.2016-0545
基金项目: 广东省自然科学基金博士启动项目(2016A030310302);广东省科学技术厅−广东省中医药科学院科研联合项目(2014A020221105).
通讯作者: 袁旭江
Email: xjyuan.xj@163.com
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