药学学报, 2017, 52(3): 347-354
引用本文:
赵凡凡, 周玉枝, 高丽, 秦雪梅, 杜冠华. D-半乳糖致衰老大鼠模型的研究进展[J]. 药学学报, 2017, 52(3): 347-354.
ZHAO Fan-fan, ZHOU Yu-zhi, GAO Li, QIN Xue-mei, DU Guan-hua. Advances in the study of the rat model of aging induced by D-galactose[J]. Acta Pharmaceutica Sinica, 2017, 52(3): 347-354.

D-半乳糖致衰老大鼠模型的研究进展
赵凡凡1,2, 周玉枝1, 高丽1, 秦雪梅1, 杜冠华1,3
1. 山西大学中医药现代研究中心, 山西 太原 030006;
2. 山西大学化学化工学院, 山西 太原 030006;
3. 中国医学科学院、北京协和医学院药物研究所, 北京 100050
摘要:
D-半乳糖(D-galactose,D-gal)致大鼠衰老模型目前已被广泛应用于抗衰老药物的药效学研究,具有寿命缩短、学习记忆障碍和免疫力降低等多种衰老特征。该模型是通过给大鼠定时、定量注射一定时间的D-半乳糖溶液,使大鼠产生类自然衰老特征,用于临床前抗衰老药物筛选、药理作用以及衰老机制的研究。但是该模型在模型的建立方面没有统一标准,不同的实验室在造模剂量、时间等方面有较大差异。因此本文主要通过总结文献报道并结合本实验室的不断探索,概述给予大鼠注射D-半乳糖溶液所致的类自然衰老模型的作用机制、方法的建立、模型成功与否的评价指标及其研究进展,并进行综合分析,为今后衰老机制的研究、抗衰老药物的开发等提供理论依据和实验参考。
关键词:    D-半乳糖      衰老模型      大鼠      造模方法      模型评价      代谢组学     
Advances in the study of the rat model of aging induced by D-galactose
ZHAO Fan-fan1,2, ZHOU Yu-zhi1, GAO Li1, QIN Xue-mei1, DU Guan-hua1,3
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;
2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China;
3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
D-galactose (D-gal)-induced aging model is widely used in the study of the pharmacodynamics of antiaging drugs. The model has a shorter life-span, disorders in learning and memory, reduced immune function and other aging characteristics. Regular and quantitative injection of D-gal solution to rats can produce symptoms of natural aging models that are used in screening of antiaging drugs, and their pharmacological activities. This paper provides a summary of the mechanism of rat model induced with D-gal solution. The methods of building and evaluation of the aging models are provided. The theoretical basis is included to facilitate the subsequent research and experiment in the mechanism study of aging and antiaging medicines.
Key words:    D-galactose    aging model    rat    model establishment method    model evaluation    metabonomics   
收稿日期: 2016-08-10
DOI: 10.16438/j.0513-4870.2016-0696
基金项目: 山西省科技基础条件平台建设项目(2014091022);山西省科技攻关项目(20140313008-14);山西省应用基础研究项目(201601D021164);山西省高校科技创新项目(2016120).
通讯作者: 周玉枝,Tel:86-351-7019178,E-mail:zhouyuzhi@sxu.edu.cn;杜冠华,Tel:86-10-63165184,E-mail:dugh@imm.ac.cn
Email: zhouyuzhi@sxu.edu.cn;dugh@imm.ac.cn
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