药学学报, 2017, 52(7): 1091-1101
李芳芳, 陆盛胜, 吉腾飞, 何坚. 动物来源放线菌的次级代谢产物及其生物活性研究进展[J]. 药学学报, 2017, 52(7): 1091-1101.
LI Fang-fang, LU Sheng-sheng, JI Teng-fei, HE Jian. Advances in secondary metabolites produced by actinobacteria derived from animal-microbe mutualism and their biological activities[J]. Acta Pharmaceutica Sinica, 2017, 52(7): 1091-1101.

李芳芳1, 陆盛胜1, 吉腾飞2, 何坚1
1. 南方医科大学药学院, 广东 广州 510515;
2. 中国医学科学院、北京协和医学院药物研究所, 北京 100050
关键词:    放线菌      次级代谢产物      生物活性      动物-细菌共同体     
Advances in secondary metabolites produced by actinobacteria derived from animal-microbe mutualism and their biological activities
LI Fang-fang1, LU Sheng-sheng1, JI Teng-fei2, HE Jian1
1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China;
2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Actinobacteria remain to be one of the major sources for new antibiotics, which historically play an essential role in human's fight against infectious diseases. Due to the emergence of resistant pathogenic microorganisms such as bacteria, fungi and viruses, it is imperative to develop new and effective drugs against these pathogens. The symbiotic actinobacteria residing inside the animals are becoming more and more important as a new source for drug discovery, as well as a "hotspot" in the field of microbial medicine. During the long period of evolution, a specific host-microbe mutualism is formed between the symbiotic bacteria and their hosts of animals. In this unique ecosystem, the secondary metabolites produced by bacteria are well tolerated by the hosts, meanwhile, are able to selectively suppress pathogenic microorganisms, thus providing a specific protection to their hosts. These secondary metabolites encompass a large variety of structural diversities of natural products, and so far, the reported biological activities are including antibacterial, antifungal, antiviral, antitumor, and immunomodulatory effects, which give them a great potential in the field of drug discovery. Herein, we review the secondary metabolites of animal symbiotic actinobacteria and their biological activities within the recent decade, by which to provide a viewpoint for future research of drug discovery from actinobacteria.
Key words:    actinobacteria    secondary metabolites    biological activities    host-microbial mutualism   
收稿日期: 2016-12-26
DOI: 10.16438/j.0513-4870.2016-1220
基金项目: 广东省科技厅资助项目(2014A020210014,2015A020211010)
通讯作者: 何坚,Tel/Fax:86-20-61648717,E-mail:jianhe@smu.edu.cn
Email: jianhe@smu.edu.cn
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陆盛胜  在本刊中的所有文章
吉腾飞  在本刊中的所有文章
何坚  在本刊中的所有文章

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1.梁林富, 刘海利, 李玉芬, 马文泉, 郭跃伟, 何文斐.锉海绵属海绵次级代谢产物及其生物活性研究进展[J]. 药学学报, 2014,49(9): 1218-1237
2.李芳芳, 陆盛胜, 吉腾飞, 何坚.动物来源放线菌的次级代谢产物及其生物活性研究进展[J]. 药学学报,