药学学报, 2017, 52(8): 1235-1240
引用本文:
毛娟, 李建明, 丁劲松. 聚(2-乙基-2-噁唑啉)在药物递送系统中的应用[J]. 药学学报, 2017, 52(8): 1235-1240.
MAO Juan, LI Jian-ming, DING Jin-song. The application of poly (2-ethyl-2-oxazoline) in drug delivery system[J]. Acta Pharmaceutica Sinica, 2017, 52(8): 1235-1240.

聚(2-乙基-2-噁唑啉)在药物递送系统中的应用
毛娟, 李建明, 丁劲松
中南大学湘雅药学院, 湖南 长沙 410013
摘要:
聚(2-乙基-2-噁唑啉)[poly(2-ethyl-2-oxazoline),PEOz]是一种由2-乙基-2-噁唑啉通过阳离子开环聚合得到的亲水性长链聚合物,具有低毒、生物相容性及分子链柔性好、易于修饰的特性。将其用于药物或载药系统的修饰可使后者具有长循环能力,而不表现出聚乙二醇(polyethylene glycol,PEG)修饰的抑制靶细胞摄取、妨碍pH敏感纳米粒"核内体逃逸"等缺点,是一种潜在的PEG替代物。本文综述了PEOz的理化性质、合成方法及其在药物递送系统中的应用。
关键词:    聚(2-乙基-2-噁唑啉)      聚乙二醇      pH-敏感      温敏      药物递送系统     
The application of poly (2-ethyl-2-oxazoline) in drug delivery system
MAO Juan, LI Jian-ming, DING Jin-song
School of Xiangya Pharmaceutical Sciences, Central South University, Changsha 410013, China
Abstract:
Poly(2-ethyl-2-oxazoline) (PEOz), a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline, has the characteristics of low toxicity, biocompatibility, flexible chain, and modified expediently. PEOz is a potential substitute of polyethylene glycol (PEG) to render the ability of long-circulation, enhance cellular uptake and endosomal escape behaviors to PEOz modified drug delivery system. In this review, we summarized recent literature for the research progress of physicochemical properties, synthetic methods and the application of PEOz in drug delivery system.
Key words:    poly(2-ethyl-2-oxazoline)    polyethylene glycol    pH-sensitive    thermosensitive    drug delivery system   
收稿日期: 2017-02-17
DOI: 10.16438/j.0513-4870.2017-0142
基金项目: 国家自然科学基金资助项目(81603061).
通讯作者: 丁劲松,Tel:86-731-82650250,E-mail:dingjs0221@163.com
Email: dingjs0221@163.com
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