药学学报, 2017, 52(8): 1299-1301
引用本文:
冯卫生, 李方, 郭孟焕, 曹彦刚, 杨雁芸, 陈文静, 齐曼, 王小兰, 郑晓珂. 怀山药中的一个新吡嗪衍生物[J]. 药学学报, 2017, 52(8): 1299-1301.
FENG Wei-sheng, LI Fang, GUO Meng-huan, CAO Yan-gang, YANG Yan-yun, CHEN Wen-jing, QI Man, WANG Xiao-lan, ZHENG Xiao-ke. A new pyrazine derivative from Dioscorea opposite Thunb.[J]. Acta Pharmaceutica Sinica, 2017, 52(8): 1299-1301.

怀山药中的一个新吡嗪衍生物
冯卫生1,2, 李方1,2, 郭孟焕1,2, 曹彦刚1,3, 杨雁芸1,2, 陈文静1,2, 齐曼1,2, 王小兰1, 郑晓珂1,2
1. 河南中医药大学药学院, 河南 郑州 450046;
2. 呼吸疾病诊疗与新药研发河南省协同创新中心, 河南 郑州 450046;
3. 黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040
摘要:
采用Diaion HP-20、Sephadex LH-20、Toyopearl HW-40、MCI Gel CHP-20、ODS、silica gel等柱色谱和半制备液相等技术,从怀山药中分离得到9个化合物,通过化合物的光谱数据和理化性质鉴定其结构分别为:2-(1',2',3'-三羟基丁基-4'-O-α-D葡萄糖苷)-6-(2",3",4"-三羟基丁基)-吡嗪(1)、尿嘧啶(2)、黄嘌呤(3)、次黄嘌呤(4)、胸腺嘧啶(5)、腺苷(6)、尿苷(7)、肌苷(8)和5'-去氧-5'-亚磺酰腺苷(9)。其中,化合物1为一个新的吡嗪衍生物,化合物3~589为首次从该植物中分离得到。
关键词:   
A new pyrazine derivative from Dioscorea opposite Thunb.
FENG Wei-sheng1,2, LI Fang1,2, GUO Meng-huan1,2, CAO Yan-gang1,3, YANG Yan-yun1,2, CHEN Wen-jing1,2, QI Man1,2, WANG Xiao-lan1, ZHENG Xiao-ke1,2
1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China;
2. Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China;
3. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Abstract:
The chemical constituents of Dioscorea opposite Thunb. were isolated and purified by Diaion HP-20, Sephadex LH-20, Toyopearl HW-40, MCI Gel CHP-20, ODS, silica gel column chromatography and semi-preparative-HPLC. Nine compounds were found and their structures were elucidated by spectral data and physicochemical properties, which were identified as 2-(1',2',3'-trihydroxybutyl-4'-O-α-D-glucopyranoside)-6-(2",3",4"-trihydroxybutyl)-pyrazine (1), uracil (2), xanthine (3), hypoxanthine (4), thymine (5), adenosine (6), uridine (7), inosine (8), and 5'-deoxy-5'-methylsulphinyladenosine (9). The compound 1 is a new pyrazine derivative, and the compound 3-5, 8, 9 are found in this plant for the first time.
Key words:   
收稿日期: 2017-03-22
DOI: 10.16438/j.0513-4870.2017-0245
基金项目: 中央引导地方科技发展专项——河南道地大宗药材种质评价及集约化种植与示范.
通讯作者: 冯卫生,Tel/Fax:86-371-60190296,E-mail:fwsh@hactcm.edu.cn
Email: fwsh@hactcm.edu.cn
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