药学学报, 2017, 52(11): 1667-1672
引用本文:
袁鹏, 郭晓辰, 张军平, 吕仕超, 朱亚萍. 外泌体作为中药载体的研究进展[J]. 药学学报, 2017, 52(11): 1667-1672.
YUAN Peng, GUO Xiao-chen, ZHANG Jun-ping, LÜ Shi-chao, ZHU Ya-ping. Research progress of the exosomes as drug delivery vehicles of Chinese herbal drugs [J]. Acta Pharmaceutica Sinica, 2017, 52(11): 1667-1672.

外泌体作为中药载体的研究进展
袁鹏1, 郭晓辰2, 张军平2, 吕仕超2, 朱亚萍2
1. 天津中医药大学 研究生院;
2. 天津中医药大学 第一附属医院, 天津 300193
摘要:
外泌体作为新型的细胞间信息交流的载体,以其在人体内广泛分布性、非免疫性与靶向性,被认为是天然的药物载体。中药能通过多靶点、多途径起到对疾病的防治作用,但其制剂品种相对单一,存在有效成分溶解度不高、生物利用度低等问题,限制了药效的更好发挥。而利用外泌体这种新型载药途径,能更好地将有效成分递送至靶细胞。本文就外泌体生物学特征及其作为中药药物载体的研究进展进行综述。
关键词:    外泌体      药物载体      中草药      纳米技术      靶向性      生物有效性      难溶型药物     
Research progress of the exosomes as drug delivery vehicles of Chinese herbal drugs
YUAN Peng1, GUO Xiao-chen2, ZHANG Jun-ping2, LÜ Shi-chao2, ZHU Ya-ping2
1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
2. The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Abstract:
As a new carrier of intercellular information, the exosomes is widely regarded as a natural drug carrier for its extensive distribution, non-immunity and targeting in human body. Chinese herbal drugs act at multiple targets and through different pathways in the prevention and treatment of diseases, but the preparation is relatively simple, there is a low solubility in the effective ingredients and low bioavailability, which limit the efficacy of the medicine. Using the new drug delivery approach of the exosomes, it is better to deliver the effective components to target cells. In this review, we reviewed the biological characteristics of exosomes and its application as a carrier of Chinese herbal drugs.
Key words:    exosome    drug carrier    Chinese herbal drug    nanotechnology    targeting    bioavailability    water-insoluble drug   
收稿日期: 2017-06-07
DOI: 10.16438/j.0513-4870.2017-0547
基金项目: 国家自然科学基金资助项目(81403217);第二批国家"万人计划"百千万工程领军人才资助.
通讯作者: 张军平
Email: tjzhtcm@163.com
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