药学学报, 2017, 52(12): 1783-1790
引用本文:
俞鸿敏, 王敏, 毛中伏, 韩方璇, 李怡芳, 栗原博, 何蓉蓉. 新型细胞死亡方式ferroptosis在肝疾病机制中的研究前景[J]. 药学学报, 2017, 52(12): 1783-1790.
YU Hong-min, WANG Min, MAO Zhong-fu, HAN Fang-xuan, LI Yi-fang, KURIHARA Hiroshi, HE Rong-rong. The prospects of ferroptosis in the pathogenesis of liver disease[J]. Acta Pharmaceutica Sinica, 2017, 52(12): 1783-1790.

新型细胞死亡方式ferroptosis在肝疾病机制中的研究前景
俞鸿敏1, 王敏2, 毛中伏1, 韩方璇2, 李怡芳1, 栗原博1, 何蓉蓉1
1. 暨南大学, 广东省中药药效物质基础和创新药物研究重点实验室, 广东 广州 510632;
2. 海南省人民医院药学部, 海南 海口 570311
摘要:
Ferroptosis是一种新型的细胞死亡方式,是铁依赖的脂质过氧化累积介导的细胞死亡。发生ferroptosis的细胞在形态学、基因学、生物化学特征上与传统的细胞死亡方式均有明显的不同。Ferroptosis已经被发现参与多种人类疾病进程,尤其在肝脏疾病中发挥着不可忽视的作用。因此,ferroptosis抑制剂或激活剂的研究,将为这些疾病的防治提供重要的药物治疗策略。本论文综述了ferroptosis生物学特征和调节信号通路,以及ferroptosis和肝脏疾病之间的关系,为探索肝脏疾病新的治疗手段提供理论依据。
关键词:    铁凋亡      活性氧      脂质过氧化作用      肝疾病     
The prospects of ferroptosis in the pathogenesis of liver disease
YU Hong-min1, WANG Min2, MAO Zhong-fu1, HAN Fang-xuan2, LI Yi-fang1, KURIHARA Hiroshi1, HE Rong-rong1
1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China;
2. Department of Pharmacy, Hainan General Hospital, Haikou 570311, China
Abstract:
Ferroptosis is a novel type of cell death which induced by iron-dependent lipid peroxidation accumulation. This type of cell death is significantly different from other cell death in terms of morphology, genetics and biochemistry. It has been reported that ferroptosis is involved in a variety of human diseases, particularly in liver diseases. Therefore, screening and studying of inhibitors or activators of ferroptosis may provide novel strategies for prevention and treatment of liver diseases. This review provides the biological characteristics and regulatory signaling pathways of ferroptosis, as well as the relationship between ferroptosis and liver diseases, which will contribute to new insight into the pathogenesis of liver diseases.
Key words:    ferroptosis    reactive oxygen species    lipid peroxidation    liver diseases   
收稿日期: 2017-07-07
DOI: 10.16438/j.0513-4870.2017-0336
基金项目: 国家自然科学基金资助项目(81622050);海南省中药现代化专项资助项目(2015ZY01).
通讯作者: 何蓉蓉,Tel:86-20-85227791,E-mail:rongronghe@jnu.edu.cn
Email: rongronghe@jnu.edu.cn
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