药学学报, 2018, 53(4): 592-597
引用本文:
肖川云, 李文艳, 翟晓晓, 朱灵芝, 周燕飞, 姚鹏程, 舒清霞, 任刚. 波罗蜜根中的异戊烯基黄酮类成分[J]. 药学学报, 2018, 53(4): 592-597.
XIAO Chuan-yun, LI Wen-yan, ZHAI Xiao-xiao, ZHU Ling-zhi, ZHOU Yan-fei, YAO Peng-cheng, SHU Qing-xia, REN Gang. Prenylated flavonoids from the roots of Artocarpus heterophyllus[J]. Acta Pharmaceutica Sinica, 2018, 53(4): 592-597.

波罗蜜根中的异戊烯基黄酮类成分
肖川云, 李文艳, 翟晓晓, 朱灵芝, 周燕飞, 姚鹏程, 舒清霞, 任刚
江西中医药大学, 中药资源与民族药研究中心, 江西 南昌 330004
摘要:
采用ODS、MCI、Sephadex LH-20、半制备HPLC等柱色谱技术对波罗蜜(桑科波罗蜜属)根的95%乙醇提取物进行了化学成分研究。从中分离得到了10个异戊烯基黄酮类成分,根据理化性质和波谱数据鉴定为artoheteroid E(1)、cycloheterophyllin(2)、artelastoxanthone(3)、artoindonesianin Q(4)、柘树黄酮C(5)、8-(γ,γ-dimethylallyl)-5,2',4'-trihydroxy-7-methoxyflavone(6)、桑皮酮T(7)、6-(3-methylbut-2-enyl)apigenin(8)、5,7,2',4'-四羟基-6-异戊烯基黄酮(9)和albanin A(10)。其中化合物1为新化合物,2~4为首次从该植物中分离得到。所有的化合物进行了抑制组织蛋白酶K(cathepsin K,CatK)活性筛选,其中化合物3~5、710对CatK具有不同程度的抑制作用,其IC50值分别为0.9、1.6、4.5、24.5、63.5μmol·L-1
关键词:    波罗蜜      化学成分      异戊烯基黄酮      cathepsin K     
Prenylated flavonoids from the roots of Artocarpus heterophyllus
XIAO Chuan-yun, LI Wen-yan, ZHAI Xiao-xiao, ZHU Ling-zhi, ZHOU Yan-fei, YAO Peng-cheng, SHU Qing-xia, REN Gang
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Abstract:
Ten isoprenylated flavonoids were isolated from 95% ethanol extraction of Artocarpus heterophyllus, with a combination of various chromatographic approaches, including ODS, MCI, CHP-20 P, Sephadex LH-20 and high performance liquid chromatography. On the basis of physic-chemical characters and spectroscopic data analysis, these compounds were identified as artoheteroid E (1), cycloheterophyllin (2), artelastoxanthone (3), artoindonesianin Q (4), cudraflavone C (5), 8-(γ,γ-dimethylallyl)-5,2',4'-trihydroxy-7-methoxyflavone (6), kuwanon T (7), 6-(3-methylbut-2-enyl) apigenin (8), 5,7,2',4'-tetrahydroxy-6-(3-methylbut-3-enyl) flavone (9), albanin A (10). Among them, compound 1 is a new one, while compounds 2-4 were isolated for the first time from the plant of Artocarpus heterophyllus. All isolated compounds were screened for their inhibitory abilities against cathepsin K. Of them, compounds 3-5, 7 and 10 showed inhibitory effects with the IC50 values of 0.9, 1.6, 4.5, 24.5 and 63.5 μmol·L-1, respectively.
Key words:    Artocarpus heterophyllus    chemical constituent    isoprenylflavonoid    cathepsin K   
收稿日期: 2017-12-28
DOI: 10.16438/j.0513-4870.2017-1305
基金项目: 国家自然科学基金资助项目(81360475,81160509);江西省青年科学家培养对象计划资助项目(20142BCB23024);江西省自然科学基金资助项目(20151BAB205074).
通讯作者: 任刚,Tel:86-791-87119067,E-mail:firmblue@163.com
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