药学学报, 2018, 53(5): 778-781
引用本文:
黄艳, 张春来, 稂文旺, 陈明生, 刘元, 刘布鸣. 毛萼清风藤中一个新的氧化阿朴菲碱类化合物[J]. 药学学报, 2018, 53(5): 778-781.
HUANG Yan, ZHANG Chun-lai, LANG Wen-wang, CHEN Ming-sheng, LIU Yuan, LIU Bu-ming. A new oxoaporphine from Sabia limoniacea var. ardisioides[J]. Acta Pharmaceutica Sinica, 2018, 53(5): 778-781.

毛萼清风藤中一个新的氧化阿朴菲碱类化合物
黄艳, 张春来, 稂文旺, 陈明生, 刘元, 刘布鸣
广西壮族自治区中医药研究院/广西中药质量标准研究重点实验室, 广西 南宁 530022
摘要:
采用硅胶柱色谱、Sephadex LH-20、制备液相等多种色谱技术,对毛萼清风藤的95%乙醇提取物进行分离纯化。从中分离得到了8个化合物,根据化合物的光谱数据和理化性质鉴定为5-甲氧基-1,2-亚甲二氧基氧化阿朴菲碱(1)、5-氧阿朴菲碱(2)、N-p-阿魏酰酪胺(3)、N-反式香豆酰酪胺(4)、槲皮素(5)、芦丁(6)、mutabiloside(7)和原儿茶酸(8)。其中,化合物1为新化合物,化合物2~8均为首次从毛萼清风藤中分离得到。
关键词:   
A new oxoaporphine from Sabia limoniacea var. ardisioides
HUANG Yan, ZHANG Chun-lai, LANG Wen-wang, CHEN Ming-sheng, LIU Yuan, LIU Bu-ming
Guangxi Institute of Chinese Medical & Pharmaceutical Sciences and Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning 530022, China
Abstract:
The chemical constituents of Sabia limoniacea var. ardisioides were investigated using chroma­tographic methods, such as silica gel, Sephadex LH-20 and preparative HPLC. Eight compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as 5-methoxy-1,2-methylenedioxyl oxoaporphine (1), fuseine (2), N-p-feruloyltyramine (3), N-trans-coumaroyl tyramin (4), quercetin (5), rutin (6), mutabiloside (7), and protocatechuic acid (8). Among those, compound 1 is a new compound, compounds 28 were isolated from this plant for the first time.
Key words:   
收稿日期: 2018-02-02
DOI: 10.16438/j.0513-4870.2018-0122
基金项目: 广西科技基地和人才专项资助项目(桂科AD16380013,桂科AD17195002).
通讯作者: 黄艳,Tel:86-771-5883405,E-mail:hy2002-2006@163.com;刘布鸣,E-mail:liu_buming@163.com
Email: hy2002-2006@163.com;liu_buming@163.com
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