药学学报, 2018, 53(7): 1017-1022
引用本文:
黄晏, 周文霞, 张永祥, 赵勤实. 钩藤碱及其同分异构体对神经系统作用的研究进展[J]. 药学学报, 2018, 53(7): 1017-1022.
HUANG Yan, ZHOU Wen-xia, ZHANG Yong-xiang, ZHAO Qin-shi. Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system[J]. Acta Pharmaceutica Sinica, 2018, 53(7): 1017-1022.

钩藤碱及其同分异构体对神经系统作用的研究进展
黄晏1, 周文霞1, 张永祥1, 赵勤实2
1. 军事科学院军事医学研究院毒物药物研究所, 抗毒药物与毒理学国家重点实验室, 北京 100850;
2. 中国科学院昆明植物研究所, 植物化学与西部植物资源持续利用国家重点实验室, 云南 昆明 650201
摘要:
钩藤是我国常用的中药之一,具有清热平肝,息风定惊之功效。生物碱类物质是钩藤的主要活性物质,现代实验药理学研究表明钩藤及其生物碱类物质对神经系统具有广泛的生物学效应,其中钩藤碱是钩藤中含量最高、研究最多的生物碱。本文就钩藤碱及其同分异构体(异钩藤碱、柯诺辛碱和柯诺辛碱B)对神经系统的作用及机制进行综述,为其应用拓展和深入研究提供参考。
关键词:    钩藤      钩藤碱      柯诺辛碱      神经系统      阿尔茨海默病      癫痫     
Research progresses in pharmacological effects of rhynchophylline and its isomers on nervous system
HUANG Yan1, ZHOU Wen-xia1, ZHANG Yong-xiang1, ZHAO Qin-shi2
1. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China;
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Abstract:
Uncaria rhynchophylla is one of the frequently used herbs in China, it is mainly used for heat-clearance, suppression of hyperactive liver, calming endogenous wind and arresting convulsion in traditional Chinese medicine (TCM). Alkaloids are the main active materials in Uncaria rhynchophylla, pharmacological studies have shown that Uncaria rhynchophylla and its alkaloids have comprehensive biological effects on the nervous system. Rhynchophylline is one of the most abundant alkaloids in Uncaria rhynchophylla. The recent studies demonstrate that rhynchophylline and its isomers (isorhynchophylline, corynoxine, corynoxine B) may be good drug candidates for treatment of Alzheimer's disease, Parkinson's disease, epilepsy, etc. Although the structures of the 4 alkaloids are very similar, they have different effects on nervous system. For example, corynoxine and corynoxine B exhibit better sedative effects than isorhynchophylline. Rhynchophylline and isorhynchophylline have been extensively studied. For development and utilization of rhynchophylline for nervous system disease, more studies are needed to unveil the structure-function relationship and the underlying mechanisms. Here, we summarizes the progresses the effects of rhynchophylline and its isomers on the nervous system.
Key words:    Uncaria rhynchophylla    rhynchophylline    corynoxine    nervous system    Alzheimer's disease    epilepsy   
收稿日期: 2018-03-22
DOI: 10.16438/j.0513-4870.2018-0250
基金项目: 国家科技重大新药创制专项资助项目(2016ZX09J16104-001).
通讯作者: 周文霞,Tel:86-10-66931625,Fax:86-10-68211656,E-mail:zhouwx@nic.bmi.ac.cn
Email: zhouwx@nic.bmi.ac.cn
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