药学学报, 2019, 54(1): 8-13
引用本文:
刘调调, 杨白雪, 郭瑛玉, 陈娜, 李三鸣. 表面活性剂的复配对姜黄素的增溶及保护作用[J]. 药学学报, 2019, 54(1): 8-13.
LIU Tiao-tiao, YANG Bai-xue, GUO Ying-yu, CHEN Na, LI San-ming. Solubilization and protection of curcumin by mixed surfactants[J]. Acta Pharmaceutica Sinica, 2019, 54(1): 8-13.

表面活性剂的复配对姜黄素的增溶及保护作用
刘调调, 杨白雪, 郭瑛玉, 陈娜, 李三鸣
沈阳药科大学药学院, 辽宁 沈阳 110016
摘要:
通过测定不同配比的十二烷基三甲基溴化铵(DTAB)和Tween 80的临界胶束浓度(CMC)、摩尔增溶比(MSR)和姜黄素(Cur)在碱性水溶液(pH 13)及表面活性剂复配碱性溶液中的降解速率(k)来考察表面活性剂的复配对姜黄素的增溶及保护作用。结果显示,单独使用Tween 80时,增溶能力强但稳定性差;单独使用DTAB时,稳定性好但是增溶能力差;二者以不同的比例复配后稳定性均增强,当DTAB摩尔分数为0.4时,稳定性最好,虽然此时增溶能力不是最好,但是相比于单独使用DTAB,MSR增加了1.7倍。表面活性剂复配在增加溶解度的同时还能增加稳定性,此外,表面活性剂复配具有用量少、毒性小等优点,值得推广。
关键词:    表面活性剂复配      临界胶束浓度      姜黄素      增溶      保护     
Solubilization and protection of curcumin by mixed surfactants
LIU Tiao-tiao, YANG Bai-xue, GUO Ying-yu, CHEN Na, LI San-ming
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Abstract:
The solubilization and protection of curcumin (Cur) by mixed surfactants were studied through the determination about the critical micellar concentration (CMC) of the mixed surfactants of Tween 80 and dodecyl trimethyl ammonium bromide (DTAB), molar solubilization ratio (MSR), degradation rate (k) of Cur in pH 13 solution and mixed surfactant solutions prepared at pH 13. The results showed that when Tween 80 was used alone, it exhibited high solubilization ability but poor stability. DTAB was used alone, it showed strong stability but poor solubilization ability. When DTAB was mixed with Tween 80 at different mole fractions, the stability of Cur was enhanced, and the best stability was observed when the mole fraction of DTAB was 0.4, although the solubilization ability was not the best at this mole fraction, but MSR was increased by 1.7 times compared to DTAB used alone. Mixed surfactant not only increased the solubility but also improved the stability of Cur. In addition, mixed surfactant has the advantages of less dosage and low toxicity, which is worth popularizing in application.
Key words:    mixed surfactant    critical micellar concentration    curcumin    solubilization    protection   
收稿日期: 2018-10-16
DOI: 10.16438/j.0513-4870.2018-0940
基金项目: 国家自然科学基金资助项目(81473161);国家科技重大专项资助项目(2017ZX09101001-006-012).
通讯作者: 李三鸣,Tel/Fax:86-24-43520581,E-mail:li_sanming@126.com
Email: li_sanming@126.com
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参考文献:
[1] Kumar A, Kaur G, Kansal SK, et al. Enhanced solubilization of curcumin in mixed surfactant vesicles[J]. Food Chem, 2016, 199:660-666.
[2] Lantz RC, Chen GJ, Solyom AM, et al. The effect of turmeric extracts on inflammatory mediator production[J]. Phytomedicine, 2005, 12:445-452.
[3] Shi M, Cai Q, Yao L, et al. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells[J]. Cell Biol Int, 2006, 30:221-226.
[4] Zhao S, Ma L, Cao C, et al. Curcumin-loaded redox response of self-assembled micelles for enhanced antitumor and anti-inflammation efficacy[J]. Int J Nanomed, 2017, 12:2489-2504.
[5] Liu J, Chen F, Tian W, et al. Optimization and characterization of curcumin loaded in octenylsuccinate oat β-glucan micelles with an emphasis on degree of substitution and molecular weight[J]. J Agric Food Chem, 2014, 62:7532-7540.
[6] Boruah B, Saikia PM, Dutta RK. Binding and stabilization of curcumin by mixed chitosan-surfactant systems:a spectroscopic study[J]. J Photoch Photobiol A, 2012, 245:18-27.
[7] Chen D, Liu Y, Fan K, et al. Relation between drug release and the drug status within curcumin-loaded microsphere[J]. Acta Pharm Sin (药学学报), 2016, 51:140-146.
[8] Simões SI, Tapadas JM, Marques CM, et al. Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, Tween 80[J]. Eur J Pharm Sci, 2005, 26:307-317.
[9] Vinarov Z, Dobreva P, Tcholakova S. Effect of surfactant molecular structure on progesterone solubilization[J]. J Drug Deliv Sci Tech, 2018, 43:44-49.
[10] Jabbari M, Teymoori F. An insight into effect of micelle-forming surfactants on aqueous solubilization and octanol/water partition coefficient of the drugs gemfibrozil and ibuprofen[J]. J Mol Liq, 2018, 262:1-7.
[11] Rangel-Yagui CO, Hsu HWL, Pessoa-Jr A, et al. Micellar solubilization of ibuprofen influence of surfactant head groups on the extent of solubilization[J]. Rev Bras Cienc Farm, 2005, 41:237-246.
[12] Clint JH. Micellization of mixed nonionic surface active agents[J]. J Chem Soc Faraday Trans, 1975, 71:1327-1334.
[13] Yadav SK, Parikh K, Kumar S. Mixed micelle formation of cationic gemini surfactant with anionic bile salt:a PAH solubilization study[J]. Colloids Surf A, 2017, 522:105-112.
[14] Stoyanova K, Vinarov Z, Tcholakova S. Improving ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles[J]. J Drug Deliv Sci Tech, 2016, 36:208-215.
[15] Yadav SK. Interaction parameters and micellisation constant of SDS and DTAB in aqueous and mixed solvents[J]. Arch Appl Sci Res, 2013, 5:105-109.
[16] Ćirin DM, Poša MM, Krstonošić VS. Interactions between sodium cholate or sodium deoxycholate and nonionic surfactant (Tween 20 or Tween 60) in aqueous solution[J]. Ind Eng Chem Res, 2012, 51:3670-3676.
[17] Wan Z, Ke D, Hong J, et al. Comparative study on the interactions of cationic gemini and single-chain surfactant micelles with curcumin[J]. Colloids Surf A, 2012, 414:267-273.
[18] Leung MH, Colangelo H, Kee TW. Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis[J]. Langmuir, 2008, 24:5672-5675.