药学学报, 2019, 54(3): 407-419
引用本文:
姜洪丽, 蒋学阳, 汤同中, 柳文媛, 冯锋, 孙昊鹏, 曲玮. 干预肿瘤代谢的新策略:氨基酸代谢的调控途径及其药物研究进展[J]. 药学学报, 2019, 54(3): 407-419.
JIANG Hong-li, JIANG Xue-yang, TANG Tong-zhong, LIU Wen-yuan, FENG Feng, SUN Hao-peng, QU Wei. A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research[J]. Acta Pharmaceutica Sinica, 2019, 54(3): 407-419.

干预肿瘤代谢的新策略:氨基酸代谢的调控途径及其药物研究进展
姜洪丽1, 蒋学阳1, 汤同中1, 柳文媛2, 冯锋1, 孙昊鹏3, 曲玮1
1. 中国药科大学天然药物化学教研室, 江苏 南京 210000;
2. 中国药科大学药物分析教研室, 江苏 南京 210000;
3. 中国药科大学药物化学系, 江苏 南京 210000
摘要:
肿瘤代谢重编程是肿瘤发生、发展过程中最关键的特征之一。许多癌症表现出对特定氨基酸的需求增加,或依赖于外源供应,或调节氨基酸代谢途径,导致相应氨基酸水平的改变以满足肿瘤发生发展的需要。因此,如能有效调节肿瘤依赖性氨基酸的水平,可在细胞代谢的角度发展全新的肿瘤治疗策略。目前本领域已经取得了令人瞩目的进展,本文概述了与肿瘤发生发展密切相关的氨基酸代谢途径,并对相应的调控机制及活性分子进行总结,最后就本领域的发展方向进行讨论与展望。
关键词:    氨基酸代谢      肿瘤      谷氨酰胺      丝氨酸      色氨酸      代谢通路      活性分子     
A new strategy to intervene tumor metabolism: regulatory targets for amino acid metabolism and advances in drug research
JIANG Hong-li1, JIANG Xue-yang1, TANG Tong-zhong1, LIU Wen-yuan2, FENG Feng1, SUN Hao-peng3, QU Wei1
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210000, China;
2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210000, China;
3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000, China
Abstract:
Reprogramming of metabolism is one of the most critical features in tumorigenesis and tumor growth. Many types of cancer show an increased demand for specific amino acids, rely on exogenous supplies, or alter amino acid metabolic pathways, leading to changes in corresponding amino acid levels to meet the need of tumorigenesis. Therefore, if the level of tumor growth-dependent amino acids can be effectively controlled, a new treatment strategy can be developed from the perspective of cell metabolism. At present, remarkable progress has been made in this field. This paper outlines the amino acid metabolic pathways closely related to tumorigenesis and tumor growth, and summarizes the corresponding regulatory mechanisms and active molecules. Finally, the direction of the field is discussed and prospected for future development.
Key words:    amino acid metabolism    cancer    glutamine    serine    tryptophan    metabolic pathway    active molecular   
收稿日期: 2018-10-23
DOI: 10.16438/j.0513-4870.2018-0969
基金项目: 国家自然科学基金资助项目(81573281);中国药科大学"双一流"建设团队项目资助(CPU2018GF11,CPU2018GY34).
通讯作者: 孙昊鹏, 曲玮
Email: sunhaopeng@163.com;popoqzh@126.com
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