药学学报, 2019, 54(3): 510-513
引用本文:
哈及尼沙, 阿卜杜热合曼·努如拉, 李改茹, 马桂芝, 程煜凤. 榅桲籽的化学成分及其PTP1B抑制活性[J]. 药学学报, 2019, 54(3): 510-513.
Hajinisa, Abdurahman NURULLA, LI Gai-ru, MA Gui-zhi, CHENG Yu-feng. Chemical constituents of Cydonia oblonga seeds and their PTP1B inhibitory effects[J]. Acta Pharmaceutica Sinica, 2019, 54(3): 510-513.

榅桲籽的化学成分及其PTP1B抑制活性
哈及尼沙, 阿卜杜热合曼·努如拉, 李改茹, 马桂芝, 程煜凤
新疆医科大学药学院, 新疆 乌鲁木齐 830011
摘要:
采用硅胶、Sephadex LH-20及半制备液相等多种色谱方法从榅桲种子中分离得到11个化合物,利用UV、1D、2D NMR、HR-ESI-MS等波谱技术分别鉴定为5,7-二羟基-2-正二十五烷基色烯-4-酮(1)、乌苏酸(2)、委陵菜酸(3)、齐墩果酸(4)、β-胡萝卜苷(5)、β-谷甾醇(6)、苦杏仁苷(7)、芦丁(8)、山柰酚(9)、槲皮素(10)和异槲皮素(11)。其中化合物1为新化合物,35为首次从榅桲属中分离得到,其他成分均为首次从榅桲籽中分离得到。用体外PTP1B抑制活性实验,化合物1~48对PTP1B有抑制活性,其IC50值分别为0.465、16.14、28.96、23.78和11.70 μmol·L-1
关键词:   
Chemical constituents of Cydonia oblonga seeds and their PTP1B inhibitory effects
Hajinisa, Abdurahman NURULLA, LI Gai-ru, MA Gui-zhi, CHENG Yu-feng
College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China
Abstract:
The chemical constituents of Cydonia oblonga (Quince) seeds were investigated using chromatographic methods, including silica gel, Sephadex LH-20 and semi-preparative-HPLC. Eleven compounds were isolated and their structures were elucidated on 1D or 2D NMR, and HR-ESI-MS. These analyses have lead to identification of 5,7-dihydroxy-2-n-pentacosanyl chromen-4-one (1), ursolic acid (2), tormentic acid (3), oleanolic acid (4), β-daucosterol (5), β-sitosterol (6), amygdalin (7), rutin (8), kaempferol (9), quercetin (10) and isoquercitrin (11). Among these, compound 1 is a new compound, and compounds 3, 5 were isolated from this plant for the first time. Compounds 1-4 and 8 showed significant PTP1B inhibitory activities with IC50 value of 0.465, 16.14, 28.96, 23.78 and 11.70 μmol·L-1, respectively.
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收稿日期: 2018-12-12
DOI: 10.16438/j.0513-4870.2018-1108
基金项目: 国家自然科学基金项目(31360078);新疆少数民族科技人才特殊培养项目(2017D03004).
通讯作者: 哈及尼沙
Email: ajinsa@sina.com
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