药学学报, 2019, 54(5): 801-807
引用本文:
向诚, 李勇, 李琨. 中药复杂系统的“多源归一”理论假说[J]. 药学学报, 2019, 54(5): 801-807.
XIANG Cheng, LI Yong, LI Kun. Hypothesis on “one output multi-source” of traditional Chinese medicine complex system[J]. Acta Pharmaceutica Sinica, 2019, 54(5): 801-807.

中药复杂系统的“多源归一”理论假说
向诚1, 李勇2, 李琨2
1. 昆明理工大学生命科学与技术学院, 云南 昆明 650500;
2. 昆明理工大学信息工程与自动化学院, 云南 昆明 650500
摘要:
针对中药复杂系统表现出的一些特殊科学事实,本文提出了一个研究中药复杂系统整体性和多成分相互作用规律的"多源归一"理论假说,包括其概念、特征、结构层次和范围,并提出假说的基本模型——人工神经网络模型,以及检验假说可能的思路、技术方法和部分证据。希望该假说能对中药复杂系统的现代科学认识有所促进,进而对中药作用物质基础、复方配伍、质量控制的研究有所推动,成为指导包括化学药、生物药和草药多分子的药物组合研究的理论基础。
关键词:    中药      复杂系统      多源归一      人工神经网络      药物组合     
Hypothesis on “one output multi-source” of traditional Chinese medicine complex system
XIANG Cheng1, LI Yong2, LI Kun2
1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;
2. Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650500, China
Abstract:
Based on special scientific facts demonstrated in traditional Chinese medicine (TCM) complex system, this paper proposes a hypothesis of "one output multi-source", discussing the concept, features, structures and the scope. The law of interaction between the integrity and multiple components of TCM complex system was examined. Feasibility, technical methods and evidence supporting the hypothesis have been presented here. We present a basic model of the hypothesis, i.e. artificial neural network (ANN) model. This hypothesis promotes a deeper modern scientific understanding towards the TCM complex system and advancement in research of the material basis. TCM compatibility and quality control will serve as the theoretical foundation for guiding the research on drug combination including chemical, biological and herbal medicines.
Key words:    traditional Chinese medicine    complex system    one output multi-source    artificial neural network    drug combination   
收稿日期: 2018-11-07
DOI: 10.16438/j.0513-4870.2018-1008
基金项目: 国家自然科学基金资助项目(81460631,81403191).
通讯作者: 向诚,Tel:86-871-65920738,Fax:86-871-65920570,E-mail:xcheng0871@163.com
Email: xcheng0871@163.com
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参考文献:
[1] Miao MS, Ma RJ, Wei RR, et al. Research technique and consid eration the proportion of the TCM components[J]. J Henan Univ (Med Sci) (河南大学学报(医学版)), 2011, 30:1-5.
[2] Ye ZG. Multi-ingredient traditional Chinese medicines prepara tions and their effective fractions[J]. Chin J New Drugs (中国新药杂志), 2011, 20:1487-1489.
[3] Liang XM, Xu Q, Xue XY, et al. Systematic research on the multi-component Chinese medicine[J]. World Sci TechnolModern Tradit Chin Med Mater Med (世界科学技术-中医药现代化), 2006, 8:1-7.
[4] Fu JH, Fu Y, Liu JX. Conception of TCD component hypothesis[J]. Chin J Inform TCM (中国中医药信息杂志), 2006, 13:52-54.
[5] Kong L, Li BC, Xiang C. Research progress on effective compounds group of Chinese materia medica[J]. Chin Tradit Herb Drugs (中草药), 2015, 46:3289-3296.
[6] Wang YL. Systems Engineering (系统工程)[M]. 4th ed. Beijing:Mechanical Industry Press, 2008.
[7] Hao HP, Zheng CN, Wang GJ. Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets[J]. Acta Pharm Sin (药学学报), 2009, 44:270-275.
[8] He FY, Luo WJ, Deng KW, et al. A survey on status and research method of pharmacokinetics of formula Chinese materia medica[J]. Chin Tradit Herb Drugs (中草药), 2005, 36:1582-1586.
[9] Xu F, Yang DH, Shang MY, et al. Effective forms, additive effect, and toxicities scattering effect of pharmacodynamic substances of TCMs some reflections evoked by the study on the metabolic disposition of traditional chinese medicines (TCM)[J]. World Sci Technol-Modern Tradit Chin Med Mater Med (世界科学技术-中医药现代化), 2014, 16:688-703.
[10] He FY, Deng KW, Liu WL, et al. Reactive essence between Chinese materia medica formula and human body:multiple genetic chromatodynamokinetics with ‘Co-network Compatibility and Rainbow Potential’[J]. Chin J Exp Tradit Med Formu (中国实验方剂学杂志), 2011, 17:240-247.
[11] Li QQ. Zuo Jinfang Multi-alkali In Vivo Network Metabolism "Rain Potential" Research (左金方多生物碱体内网络代谢"虹势性"研究)[D]. Changsha:Hunan University of Chinese Medicine, 2009.
[12] Kang SY, Zhang JQ, Zhang AJ, et al. Based on urine metabolo mics to study effect of Liuwei Dihuang Wan on growth and development of rats[J]. Acta Pharm Sin (药学学报), 2018, 53:1713-1720.
[13] Xiang Z, Cai XJ, Zeng S. Thoughts and exploration on pharma cokinetic study of herbal medicines based on metabonomics and complex network[J]. Acta Pharm Sin (药学学报), 2012, 47:558-564.
[14] Pang XC, Wang Z, Fang JS, et al. Network pharmacology study of effective constituents of traditional Chinese medicine for Alzheimer's disease treatment[J]. Acta Pharm Sin (药学学报), 2016, 51:725-731.
[15] Xiang C, Qiao X, Wang Q, et al. From single compounds to herbal extract:a strategy to systematically characterize the metabolites of licorice in rats[J]. Drug Metabol Disposit, 2011, 39:1597-1608.
[16] Qiao X, Ye M, Xiang C, et al. Analytical strategy to reveal the in vivo process of multi-component herbal medicine:a pharmaco kinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry[J]. J Chromatogr A, 2012, 1258:84-93.
[17] Fu SP, Wang LX, Zhang F, et al. Determination of ligustrazin and ferulic acid in Si-wu-tang and its related preparations by capillary zone electrophoresis[J]. Chin J Chromatogr (色谱), 2003, 21:371-374.
[18] Spiro M, Page CM. The kinetics and mechanism of caffeine infusion from coffee:hydrodynamic aspects[J]. J Sci Food Agr, 1984, 35:925-930.
[19] Spiro M, Jaganyi D. Kinetics and equilibria of tea infusion, Part 15. Transport of caffeine across a teabag membrane in a modi fied rotating diffusion cell[J]. Food Chem, 2000, 69:119-124.
[20] Spiro M, Chong YY. The kinetics and mechanism of caffeine infusion from coffee:the temperature variation of the hindrance factor[J]. J Sci Food Agr, 1997, 74:416-420.
[21] Chu MQ, Liu GJ. Kinetic model for extraction process of Chinese traditional medicine[J]. Acta Pharm Sin (药学学报), 2002, 37:559-562.
[22] He FY, Deng KW, Luo JY, et al. Fundamentally study on mathe matical kinetic model of component extraction from FTCM[J]. China J Chin Mater Med (中国中药杂志), 2007, 32:490-495.
[23] Wang BC, Su H, Yang X, et al. Kinetic models for extraction process of natural products[J]. Chin Tradit Patent Med (中成药), 2012, 34:2309-2312.
[24] He FY, Deng KW, Wu DZ, et al. Extraction kineticai deviations of berberine alkaloids in Rhizoma Coptidis and Zuojin Formulae[J]. Chin Tradit Patent Med (中成药), 2009, 31:1354-1359.
[25] Yuan ST, Du HY, Xia K. The effect of Chinese herbal compound decoction on the dissolution effect[J]. Chin J Inform TCM (中国中医药信息杂志), 1999, 6:29-32.
[26] Tang ZS, Guo LW. Establishment of scientific principles on evaluation system for compound Chinese materia medica extrac tion and separation[J]. Chin Tradit Herb Drugs (中草药), 2010, 41:841-845.
[27] Su H, Wang BC, Liu WQ, et al. Kinetic mathematical models for extraction process of natural medicines[J]. Chin Tradit Herb Drugs (中草药), 2011, 42:384-391.
[28] Luo GA, Wang YM, Liang QL, et al. Chinese Medicine Systems Biology (中医药系统生物学)[M]. Beijing:Science Press, 2011.
[29] Chou TC. Theoretical basis, experimental design, and comput erized simulation of synergism and antagonism in drug combina tion studies[J]. Pharmacol Rev, 2006, 58:621-681.
[30] Chou TC, Martin N. CompuSyn for drug combinations PC software and user's guide:a computer program for quantitation of synergism and antagonism in drug combinations, andthe deter mination of IC 50 and ED50 and LD50 values[J/OL]. Paramus:ComboSyn, 2005.
[31] Long F, Yang H, Xu YM, et al. A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines[J]. Sci Rep, 2015, 5:12361.
[32] Lam W, Jiang ZL, Guan FL, et al. PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the antitumor activity of sorafenib by changing the tumor microenviron ment[J]. Sci Rep, 2015, 5:9384.
[33] Gong P, Cui N, Wu L, et al. Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures[J]. Anal Chem, 2012, 84:2995-3002.
[34] Chen HX, Cui FX, Li H, et al. Metabolic changes during the pu-erh tea pile-fermentation revealed by a liquid chromatography tandem mass-spectrometry-based metabolomics approach[J]. J Food Sci, 2013, 78:C1665-C1672.
[35] Yan R, Yang Y, Chen YJ. Pharmacokinetics of Chinese medicines:strategies and perspectives[J]. Chin Med, 2018, 13:24.
[36] Li C. Multi-compound pharmacokinetic research on Chinese herbal medicines:approach and methodology[J]. China J Chin Mater Med (中国中药杂志), 2017, 42:607-617.