药学学报, 2019, 54(5): 892-896
引用本文:
元超, 郭玉华, 张影波, 王鸿发, 胡璇, 王丹, 官玲亮, 于福来, 李刚. 艾纳香内生真菌Corynespora cassiicola J9次生代谢产物研究[J]. 药学学报, 2019, 54(5): 892-896.
YUAN Chao, GUO Yu-hua, ZHANG Ying-bo, WANG Hong-fa, HU Xuan, WANG Dan, GUAN Ling-liang, YU Fu-lai, LI Gang. Secondary metabolites from Corynespora cassiicola J9, an endophytic fungus associated with Blumea balsamifera (L.) DC.[J]. Acta Pharmaceutica Sinica, 2019, 54(5): 892-896.

艾纳香内生真菌Corynespora cassiicola J9次生代谢产物研究
元超1,3, 郭玉华4, 张影波1,3, 王鸿发1,3, 胡璇1,3, 王丹1,3, 官玲亮1,3, 于福来1,3, 李刚2
1. 中国热带农业科学院热带作物品种资源研究所, 海南 儋州 571737;
2. 青岛大学药学院天然药物与生药学系, 山东 青岛 266021;
3. 海南省艾纳香工程技术研究中心, 海南 儋州 571737;
4. 山东药品食品职业技术学院, 山东 威海 264210
摘要:
对分离自海南植物艾纳香的一株内生真菌Corynespora cassiicola J9进行次生代谢产物研究,通过多种色谱技术从其大米培养基中分离获得了8个化合物,包括1个新的缩酚酸环醚类化合物corynether C(1)和7个已知缩酚酸环醚类似物:corynether B(2)、corynetherlactone A(3)、corynether A(4)、diaryl ether(5)、corynesidone C(6)、corynesidone D(7)和corynesidone A(8)。采用一维和二维核磁共振谱和高分辨电喷雾质谱技术对化合物结构进行了确证。叶片喷洒饲喂法抗稻水象甲活性评价显示,所有供试化合物均无杀象甲活性。
关键词:    艾纳香      植物内生真菌      缩酚酸环醚      杀虫活性      次生代谢产物     
Secondary metabolites from Corynespora cassiicola J9, an endophytic fungus associated with Blumea balsamifera (L.) DC.
YUAN Chao1,3, GUO Yu-hua4, ZHANG Ying-bo1,3, WANG Hong-fa1,3, HU Xuan1,3, WANG Dan1,3, GUAN Ling-liang1,3, YU Fu-lai1,3, LI Gang2
1. Tropical Crops Genetic Resources Institute, CATAS, Danzhou 571737, China;
2. Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China;
3. Hainan Engineering Research Center for Blumea balsamifera, Danzhou 571737, China;
4. Shandong Drug and Food Vocational College, Weihai 264210, China
Abstract:
Chemical investigation on the rice culture of Corynespora cassiicola J9, an endophyte inhabiting in Blumea balsamifera (L.) DC. resulted in isolation of eight compounds, including a new depsidone derivative, corynether C (1), and seven analogues, corynether B (2), corynetherlactone A (3), corynether A (4), diaryl ether (5), corynesidone C (6), corynesidone D (7), and corynesidone A (8). Their structures were deduced based on 1D and 2D NMR spectroscopy, and HR-ESI-MS data. All of the isolated compounds were evaluated for inhibitory activities against Lissorhoptrus oryzophilus Kuschel by the leaf spray assay. Unfortunately, none of them showed inhibitory effects.
Key words:    Blumea balsamifera (L.) DC.    fungal endophyte    depsidone    pesticide activity    secondary metabolite   
收稿日期: 2019-02-15
DOI: 10.16438/j.0513-4870.2019-0112
基金项目: 中国热带农业科学院基本科研业务费专项资金资助项目(1630032019045);海南省自然科学基金资助项目(219MS079)
通讯作者: 李刚,Tel:86-532-82991202,E-mail:gang.li@qdu.edu.cn
Email: gang.li@qdu.edu.cn
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