药学学报, 2019, 54(6): 984-990
引用本文:
谭成勇, 田慧珍, 况煌, 洪芬芳, 杨树龙. 药物调节自噬治疗阿尔茨海默病[J]. 药学学报, 2019, 54(6): 984-990.
TAN Cheng-yong, TIAN Hui-zhen, KUANG Huang, HONG Fen-fang, YANG Shu-long. Medications regulate autophagy for treatment of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2019, 54(6): 984-990.

药物调节自噬治疗阿尔茨海默病
谭成勇1, 田慧珍1, 况煌1, 洪芬芳2, 杨树龙1
1. 南昌大学基础医学院, 江西 南昌 330031;
2. 南昌大学基础医学实验教学中心, 江西 南昌 330006
摘要:
阿尔茨海默病(Alzheimer's disease,AD)是以认知功能障碍为临床表现的疾病。过去虽然对AD发病机制研究取得了显著进展,但阻断AD病情发展的有效治疗方法并不令人满意。自噬(autophagy)异常被认为参与AD发病机制,自噬的调节可能成为AD治疗新策略。经mTOR依赖性和非依赖性(Bcl-2/Beclin-1、GSK-3β和p-AKT等)途径调节自噬的药物显示出很好的缓解AD症状作用。此外,一些从植物中提取出的化合物也被报道可经多途径、多靶标调节自噬阻止AD进展。本文对近期有关药物包括植物提取药物调节自噬治疗AD的研究进展作一综述,为临床治疗AD提供新的理论基础。
关键词:    自噬      阿尔茨海默病      植物提取化合物      药物     
Medications regulate autophagy for treatment of Alzheimer's disease
TAN Cheng-yong1, TIAN Hui-zhen1, KUANG Huang1, HONG Fen-fang2, YANG Shu-long1
1. College of Basic Medicine, Nanchang University, Nanchang 330031, China;
2. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China
Abstract:
Alzheimer's disease (AD) is characterized clinically as irreversible cognitive dysfunction. Although a significant progress has been made in the study of AD pathogenesis, the effective measures to block AD progress have not been satisfactory. Abnormal autophagy is thought to be involved in the pathogenesis of AD, and regulation of autophagy may become a new strategy for AD treatment. Some medicines, which regulate autophagy by mTOR-dependent and independent (Bcl-2/Beclin-1, GSK-3β, and p-AKT) pathways, have shown excellent effects in alleviating AD symptoms. In addition, certain compounds extracted from plants have also been reported to regulate autophagy and prevent AD progression through multiple pathways and multiple targets. This article reviews the recent advances in the regulation of autophagy and AD treatment. It provides a new theoretical basis for clinical treatment of AD.
Key words:    autophagy    Alzheimer's disease    plant extract compound    medicine   
收稿日期: 2018-12-10
DOI: 10.16438/j.0513-4870.2018-1107
基金项目: 国家自然科学基金资助项目(81660751,81660151,81260504);江西省重点研发计划(20161BBG70067);江西省自然科学基金资助项目(2017BAB205085).
通讯作者: 洪芬芳, 杨树龙
Email: hongfenfang@126.com;slyang@ncu.edu.cn
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