药学学报, 2019, 54(7): 1257-1259
引用本文:
武婷, 张茂生, 张建永, 李晓飞, 徐德林, 肖世基. 金钗石斛中一个新的卡达烯型倍半萜葡萄糖苷[J]. 药学学报, 2019, 54(7): 1257-1259.
WU Ting, ZHANG Mao-sheng, ZHANG Jian-yong, LI Xiao-fei, XU De-lin, XIAO Shi-ji. A new cadalene sesquiterpene glycoside from Dendrobium nobile[J]. Acta Pharmaceutica Sinica, 2019, 54(7): 1257-1259.

金钗石斛中一个新的卡达烯型倍半萜葡萄糖苷
武婷1, 张茂生1, 张建永1, 李晓飞2, 徐德林3, 肖世基1,2
1. 遵义医科大学药学院, 贵州 遵义 563006;
2. 遵义医科大学贵州省兰科药用植物繁育及高效应用工程研究中心, 贵州 遵义 563006;
3. 遵义医科大学基础医学院, 贵州 遵义 563006
摘要:
通过各种色谱分离方法从贵州道地药材金钗石斛茎的醇提物非生物碱部分分离得到1个新的卡达烯型倍半萜葡萄糖苷,其结构经质谱和核磁共振等波谱技术鉴定,命名为卡达烯-12-O-β-D-葡萄糖苷。该类化合物骨架生源上由杜松烷型倍半萜高度去氢形成萘环得到卡达烯型倍半萜,此类化合物的糖苷在天然产物中较少见。
关键词:    金钗石斛      兰科      倍半萜      葡萄糖苷      卡达烯     
A new cadalene sesquiterpene glycoside from Dendrobium nobile
WU Ting1, ZHANG Mao-sheng1, ZHANG Jian-yong1, LI Xiao-fei2, XU De-lin3, XIAO Shi-ji1,2
1. School of Pharmacy, Zunyi Medical University, Zunyi 563006, China;
2. Guizhou Provincial Research Center for the Propagation and Efficient Utilization of Medicinal Orchids, Zunyi Medical University, Zunyi 563006, China;
3. School of Basic Medical Sciences, Zunyi Medical University, Zunyi 563006, China
Abstract:
Using column chromatographic and preparative HPLC technologies, we isolated a new sesquiterpene glycoside from the stem of Dendrobium nobile. With spectroscopic techniques including NMR and MS, the new compound was identified as cadalene-12-O-β-D-glucopyranoside. This type of compound was dehydrogenated from cadinane sesquiterpene to achieve a naphthalene ring, and it is rare from a natural resource.
Key words:    Dendrobium nobile    Orchidaceae    sesquiterpene    glycoside    cadalene   
收稿日期: 2019-04-04
DOI: 10.16438/j.0513-4870.2019-0234
基金项目: 国家自然科学基金资助项目(31560102);贵州省教育厅自然科学研究项目(黔教合KY字[2015]362);贵州省科技重大专项子项目(黔科合重大专项字[2015]6010-2).
通讯作者: 肖世基,Tel:86-851-28642513,Fax:86-851-28609343,E-mail:xiaoshiji84@163.com
Email: xiaoshiji84@163.com
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