药学学报, 2019, 54(8): 1493-1501
引用本文:
田娟娟, 余雅婷, 赵立杰, 冯怡, 王优杰, 沈岚. 介孔二氧化硅固化柴翘挥发油及其粉体学性质的研究[J]. 药学学报, 2019, 54(8): 1493-1501.
TIAN Juan-juan, YU Ya-ting, ZHAO Li-jie, FENG-Yi, WANG You-jie, SHEN Lan. Mesoporous silica solidifying volatile oil from Bupleuri radix and forsythiae fructus and its micromeritic properties[J]. Acta Pharmaceutica Sinica, 2019, 54(8): 1493-1501.

介孔二氧化硅固化柴翘挥发油及其粉体学性质的研究
田娟娟1, 余雅婷2, 赵立杰2, 冯怡2, 王优杰2, 沈岚1
1. 上海中医药大学中药学院, 上海 201203;
2. 上海中医药大学中药现代制剂技术教育部工程研究中心, 上海 201203
摘要:
本研究的目的是以介孔二氧化硅Sylysia 350FCP为载体固化柴翘挥发油,并考察载体粉末载药前后粉体学性质的变化。通过简单的搅拌工艺,制得挥发油固化粉末,并以休止角、粒径、堆密度、真密度和孔隙率等为指标评价粉末的粉体学性质;以塑性常数、出片力、摩擦功和抗张强度等为指标评价粉末的压缩成型性;采用扫描电镜、粉末X-射线衍射和同步热分析等方法对粉末进行表征,同时对固化粉末的热稳定性和机械稳定性等关键属性进行研究。结果表明,以介孔二氧化硅作为载体固化挥发油,具有载药量大、高热稳定性和高机械稳定性,且载药后粉末不影响其作为固体润滑剂、助流剂的优良特性,对物料的压缩过程及成型性均无影响,并能够满足工业化生产需求的优势。
关键词:    介孔二氧化硅      挥发油      粉体学性质      物相表征      稳定性     
Mesoporous silica solidifying volatile oil from Bupleuri radix and forsythiae fructus and its micromeritic properties
TIAN Juan-juan1, YU Ya-ting2, ZHAO Li-jie2, FENG-Yi2, WANG You-jie2, SHEN Lan1
1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Abstract:
The aim of this study is to solidify the volatile oil (VO) of Bupleuri radix and forsythiae fructus by using mesoporous silica Sylysia 350FCP (Sylysia 350FCP) as carrier, and to investigate the changes of micromeritic properties before and after drug loading. The volatile oil drug-loading powder (VO-DLP) was prepared by blending process. The micromeritic properties were evaluated by angle of repose, particle size, bulk density, true density and porosity. The compressibility and compactibility of the powder were evaluated by plastic strain energy, ejection force, friction energy and tensile strength. The powder was characterized by scanning electron microscopy, powder X-ray diffraction and synchronous thermal analysis. In addition, the thermal stability, mechanical stability and other key properties of VO-DLP were investigated. We found that mesoporous silica as a carrier of solidifying volatile oil has the advantages for large drug load, high thermal stability, and high mechanical stability. In addition, the excellent properties of mesoporous silica as solid lubricant and glidant are not affected after loading VO, and has no effect on the compression process and compactibility of materials. What's more, it can meet the demand of continuous production.
Key words:    mesoporous silica    volatile oil    micromeritic property    physical characterization    stability   
收稿日期: 2019-04-03
DOI: 10.16438/j.0513-4870.2019-0235
通讯作者: 沈岚,Tel/Fax:86-21-51323030,E-mail:alansusu@sina.com;赵立杰,Tel:86-21-51322766,Fax:86-21-51322491,E-mail:zhaolijie761029@126.com
Email: alansusu@sina.com;zhaolijie761029@126.com
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