药学学报, 2019, 54(8): 1333-1347
引用本文:
李继新, 李艺冉, 罗俊, 孔令义. 2018年中国天然产物研究亮点[J]. 药学学报, 2019, 54(8): 1333-1347.
LI Ji-xin, LI Yi-ran, LUO Jun, KONG Ling-yi. Highlights of natural products research from China in 2018[J]. Acta Pharmaceutica Sinica, 2019, 54(8): 1333-1347.

2018年中国天然产物研究亮点
李继新, 李艺冉, 罗俊, 孔令义
中国药科大学中药学院, 江苏 南京 210009
摘要:
结构多样、生物活性显著的天然产物是药物先导化合物的重要来源,对创新药物的研发具有十分重要的作用。在从天然药物中发现并分离结构多样的活性天然产物领域,近年来我国一直处于国际领先地位。在2018年中,中国学者在天然产物研究领域取得了诸多成果,一系列结构新颖、生物活性显著的天然分子被发现和研究,其中73个化合物被国际权威期刊Nat Prod Rep评为热点化合物。本文选取了中国学者在2018年度发表于国内外天然产物研究领域著名期刊的123个天然产物,对它们的来源、结构特征和生物活性进行简要介绍,以期反映2018年中国天然产物研究的亮点。
关键词:    纳米粒      聚乙烯己内酰胺-聚乙酸乙烯酯-聚乙二醇接枝共聚物      帕比司他      表面疏水性      黏附素      天然产物      新颖结构      生物活性      研究亮点     
Highlights of natural products research from China in 2018
LI Ji-xin, LI Yi-ran, LUO Jun, KONG Ling-yi
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Abstract:
Natural products with diverse structures and significant biological activities were important source of lead compounds, and have played a key role in the innovative drug development. Recently, China has been in the prior position in discovering of structurally diverse active natural products from natural medicines. In 2018, a series of natural products with novel structures and significant biological activities have been isolated and studied by scholars from China, and 73 molecules with novel carbon frameworks have been selected as "Hot of The Press" by Nat Prod Rep Journal. In this review, the original, structures and biological activities of 123 compounds of natural products research field in 2018 were briefly described, which was aimed to exhibit the highlights of natural products research from China in past year.
Key words:    nanoparticle    polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer    panobinostat    surface hydrophobicity    mucins    natural product    novel structure    biological activity    research highlight   
收稿日期: 2019-05-30
DOI: 10.16438/j.0513-4870.2019-0425
通讯作者: 孔令义,Tel:86-25-83271402,E-mail:cpu_lykong@126.com.
Email: cpu_lykong@126.com
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