药学学报, 2019, 54(8): 1382-1391
引用本文:
李萌茹, 周玉枝, 杜冠华, 秦雪梅. 中药黄酮类化合物抗衰老作用及其机制研究进展[J]. 药学学报, 2019, 54(8): 1382-1391.
LI Meng-ru, ZHOU Yu-zhi, DU Guan-hua, QIN Xue-mei. Research progress about the anti-aging effect and mechanism of flavonoids from traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2019, 54(8): 1382-1391.

中药黄酮类化合物抗衰老作用及其机制研究进展
李萌茹1, 周玉枝1, 杜冠华1,2, 秦雪梅1
1. 山西大学中医药现代研究中心, 山西 太原 030006;
2. 中国医学科学院药物研究所, 北京 100050
摘要:
衰老是生命过程中的一种自然现象,是机体内外多种因素共同作用的结果。现阶段,国内外科研工作者对抗衰老和具有抗衰老活性的天然产物的研究还远远不够,仍需积极探索和开发。近年来,许多科研工作者发现中药中含有的黄酮类活性成分能够延缓神经系统、免疫器官、生殖系统、肝脏和皮肤等组织的衰老。因此,积极探索和开发中药黄酮类抗衰老药物,对提高老年人的生命质量、减缓社会人口老龄化具有重要意义。目前,对于这类物质抗衰老的作用机制尚未完全清楚,因此本文将以现代衰老学说为基础,从细胞信号转导通路和代谢通路两方面探讨中药黄酮类化合物的抗衰老作用及其涉及的作用机制。
关键词:    黄酮类化合物      抗氧化      抗衰老      自由基理论      细胞信号转导通路      代谢通路     
Research progress about the anti-aging effect and mechanism of flavonoids from traditional Chinese medicine
LI Meng-ru1, ZHOU Yu-zhi1, DU Guan-hua1,2, QIN Xue-mei1
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;
2. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
Abstract:
Aging is a normal physiological process involving coaction of many factors. The anti-aging effects of natural products have been studied by many domestic and international scholars, but not far enough, which still needed to be explored. Flavonoids, as natural products, have a variety of pharmacological activities and present in many traditional Chinese medicines. In recent years, research results indicate that flavonoids can delay the aging process of the nervous, immune, and reproductive systems, and the liver, skin and other tissues. The anti-aging effects of flavonoids have attracted more and more attention. Therefore, development of anti-aging drugs from flavonoids is of great significance to improve the quality of life for the elderly and slow the process of aging. However, the mechanism of the anti-aging effect of flavonoids remains unknown at present. This review will discuss the anti-aging effect and mechanisms of flavonoids in traditional Chinese medicine from the aspects of cellular signaling pathways and metabolic pathways based on the modern theories of aging.
Key words:    flavonoids    antioxidant    anti-aging    free radical theory    cellular signaling pathway    metabolic pathway   
收稿日期: 2019-04-16
DOI: 10.16438/j.0513-4870.2019-0283
基金项目: 山西省重点研发计划项目(201703D321023-3).
通讯作者: 周玉枝,Tel:86-351-7019178,E-mail:zhouyuzhi@sxu.edu.cn;秦雪梅,Tel:86-351-7011501,E-mail:qinxm@sxu.edu.cn
Email: zhouyuzhi@sxu.edu.cn;qinxm@sxu.edu.cn
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