药学学报, 2019, 54(8): 1402-1408
引用本文:
秦雪梅, 高耀, 田俊生, 邢婕, 高晓霞, 周玉枝, 杜冠华. 从柴胡药材质量评价到抗抑郁新药开发的研究思路与策略[J]. 药学学报, 2019, 54(8): 1402-1408.
QIN Xue-mei, GAO Yao, TIAN Jun-sheng, XING Jie, GAO Xiao-xia, ZHOU Yu-zhi, DU Guan-hua. Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs[J]. Acta Pharmaceutica Sinica, 2019, 54(8): 1402-1408.

从柴胡药材质量评价到抗抑郁新药开发的研究思路与策略
秦雪梅1,2, 高耀1,2, 田俊生1,2, 邢婕1,2, 高晓霞1,2, 周玉枝1,2, 杜冠华3
1. 山西大学中医药现代研究中心, 山西 太原 030006;
2. 山西大学地产中药功效物质研究与利用山西省重点实验室, 山西 太原 030006;
3. 中国医学科学院、北京协和医学院药物研究所, 北京 100050
摘要:
中药资源开发与利用是中药现代化的重要内容,中医经典方剂是中药新药研发的重要途径。立足当地中药材资源优势,围绕药材质量评价与中医方剂研究中的关键科学问题,形成以药材质量评价为出发点,以重大需求和科学问题为导向,以代谢组学技术为手段的"中药材质量评价-中医方剂科学内涵挖掘-中药新药研发"研究思路与策略。本文以柴胡药材为例,从药材质量评价、逍遥散基础研究、抗抑郁新药研发等方面系统深入地阐述上述研究思路与策略,为中药现代化发展提供科学依据。
关键词:    柴胡      质量评价      逍遥散      抗抑郁      新药研发      研究策略     
Ideas and strategies from quality evaluation of Radix Bupleurum for development of new anti-depressant drugs
QIN Xue-mei1,2, GAO Yao1,2, TIAN Jun-sheng1,2, XING Jie1,2, GAO Xiao-xia1,2, ZHOU Yu-zhi1,2, DU Guan-hua3
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;
2. Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Shanxi University, Taiyuan 030006, China;
3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Abstract:
Utilization of traditional Chinese medicine (TCM) resources for pharmaceutical development is an important part of modernization of TCM. The classical TCM prescriptions provide an important insight for developing new drugs. Based on the advantages of local TCM resources, focusing on the key scientific problems in the quality evaluation of medicinal materials and the study of classical prescriptions, this research group takes the quality evaluation of medicinal materials as the starting point. Metabolomics serves as a technical means of "quality evaluation of TCM, to support scientific connotation of classical prescriptions and development of new drugs from TCM. Using Radix Bupleurum as an example, this paper systematically and thoroughly expounds the above research ideas and strategies from the aspects:quality evaluation of medicinal materials, basic research of Xiaoyansan, and research and development of new anti-depressants. This provides the scientific basis for the modernization of TCM.
Key words:    Radix Bupleurum    quality evaluation    Xiaoyaosan    antidepressant    new drug research and development    research strategy   
收稿日期: 2019-04-02
DOI: 10.16438/j.0513-4870.2019-0229
基金项目: 国家“重大新药创制”科技重大专项(2017ZX09301047);山西省科技重点研发计划项目(201603D3113013,201603D321077);山西省自然科学基金项目(201701D121137);山西省重点实验室资助项目(201605D111004);山西省科技创新重点团队资助项目(201605D131045-18);山西省研究生教育创新项目(2017JD02).
通讯作者: 秦雪梅,Tel:86-351-7019297,Fax:86-351-7018397,E-mail:qinxm@sxu.edu.cn
Email: qinxm@sxu.edu.cn
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